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Lung Ultrasound in COVID-19: Clinical Correlates and Comparison with Chest Computed Tomography

Lung ultrasound (LUS) and chest computed tomography (chest CT) are largely employed to evaluate coronavirus disease 2019 (COVID-19) pneumonia. We investigated semi-quantitative LUS and CT scoring in hospitalized COVID-19 patients. LUS and chest CT were performed within 24 h upon admission. Both were...

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Autores principales: Portale, Grazia, Ciolina, Federica, Arcari, Luca, Giraldi, Gianluca Di Lazzaro, Danti, Massimiliano, Pietropaolo, Lorenzo, Camastra, Giovanni, Cordischi, Chiara, Urbani, Laura, Proietti, Lidia, Cacciotti, Luca, Santini, Claudio, Melandri, Serena, Ansalone, Gerardo, Sbarbati, Stefano, Sighieri, Cinzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211720/
https://www.ncbi.nlm.nih.gov/pubmed/34179691
http://dx.doi.org/10.1007/s42399-021-00986-1
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author Portale, Grazia
Ciolina, Federica
Arcari, Luca
Giraldi, Gianluca Di Lazzaro
Danti, Massimiliano
Pietropaolo, Lorenzo
Camastra, Giovanni
Cordischi, Chiara
Urbani, Laura
Proietti, Lidia
Cacciotti, Luca
Santini, Claudio
Melandri, Serena
Ansalone, Gerardo
Sbarbati, Stefano
Sighieri, Cinzia
author_facet Portale, Grazia
Ciolina, Federica
Arcari, Luca
Giraldi, Gianluca Di Lazzaro
Danti, Massimiliano
Pietropaolo, Lorenzo
Camastra, Giovanni
Cordischi, Chiara
Urbani, Laura
Proietti, Lidia
Cacciotti, Luca
Santini, Claudio
Melandri, Serena
Ansalone, Gerardo
Sbarbati, Stefano
Sighieri, Cinzia
author_sort Portale, Grazia
collection PubMed
description Lung ultrasound (LUS) and chest computed tomography (chest CT) are largely employed to evaluate coronavirus disease 2019 (COVID-19) pneumonia. We investigated semi-quantitative LUS and CT scoring in hospitalized COVID-19 patients. LUS and chest CT were performed within 24 h upon admission. Both were analyzed according to semi-quantitative scoring systems. Subgroups were identified according to median LUS score. Patients within higher LUS score group were older (79 vs 60 years, p<0.001), had higher C-reactive protein (CRP) (7.2 mg/dl vs 1.3 mg/dl, p<0.001) and chest CT score (10 vs 4, p=0.027) as well as lower PaO2/FiO2 (286 vs 356, p=0.029) as compared to patients within lower scores. We found a significant correlation between scores (r=0.390, p=0.023). Both LUS and CT scores correlated directly with patients age (r=0.586, p<0.001 and r=0.399, p=0.021 respectively) and CRP (r=0.472, p=0.002 and r=0.518, p=0.002 respectively), inversely with PaO2/FiO2 (r=−0.485, p=0.003 and r=−0.440, p=0.017 respectively). LUS score only showed significant correlation with hs-troponin T, NT-pro-BNP, and creatinine (r=0.433, p=0.019; r=0.411, p=0.027, and r=0.497, p=0.001, respectively). Semi-quantitative bedside LUS is related to the severity of COVID-19 pneumonia similarly to chest CT. Correlation of LUS score with markers of cardiac and renal injury suggests that LUS might contribute to a more comprehensive evaluation of this heterogeneous population.
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spelling pubmed-82117202021-06-21 Lung Ultrasound in COVID-19: Clinical Correlates and Comparison with Chest Computed Tomography Portale, Grazia Ciolina, Federica Arcari, Luca Giraldi, Gianluca Di Lazzaro Danti, Massimiliano Pietropaolo, Lorenzo Camastra, Giovanni Cordischi, Chiara Urbani, Laura Proietti, Lidia Cacciotti, Luca Santini, Claudio Melandri, Serena Ansalone, Gerardo Sbarbati, Stefano Sighieri, Cinzia SN Compr Clin Med Covid-19 Lung ultrasound (LUS) and chest computed tomography (chest CT) are largely employed to evaluate coronavirus disease 2019 (COVID-19) pneumonia. We investigated semi-quantitative LUS and CT scoring in hospitalized COVID-19 patients. LUS and chest CT were performed within 24 h upon admission. Both were analyzed according to semi-quantitative scoring systems. Subgroups were identified according to median LUS score. Patients within higher LUS score group were older (79 vs 60 years, p<0.001), had higher C-reactive protein (CRP) (7.2 mg/dl vs 1.3 mg/dl, p<0.001) and chest CT score (10 vs 4, p=0.027) as well as lower PaO2/FiO2 (286 vs 356, p=0.029) as compared to patients within lower scores. We found a significant correlation between scores (r=0.390, p=0.023). Both LUS and CT scores correlated directly with patients age (r=0.586, p<0.001 and r=0.399, p=0.021 respectively) and CRP (r=0.472, p=0.002 and r=0.518, p=0.002 respectively), inversely with PaO2/FiO2 (r=−0.485, p=0.003 and r=−0.440, p=0.017 respectively). LUS score only showed significant correlation with hs-troponin T, NT-pro-BNP, and creatinine (r=0.433, p=0.019; r=0.411, p=0.027, and r=0.497, p=0.001, respectively). Semi-quantitative bedside LUS is related to the severity of COVID-19 pneumonia similarly to chest CT. Correlation of LUS score with markers of cardiac and renal injury suggests that LUS might contribute to a more comprehensive evaluation of this heterogeneous population. Springer International Publishing 2021-06-18 2021 /pmc/articles/PMC8211720/ /pubmed/34179691 http://dx.doi.org/10.1007/s42399-021-00986-1 Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Covid-19
Portale, Grazia
Ciolina, Federica
Arcari, Luca
Giraldi, Gianluca Di Lazzaro
Danti, Massimiliano
Pietropaolo, Lorenzo
Camastra, Giovanni
Cordischi, Chiara
Urbani, Laura
Proietti, Lidia
Cacciotti, Luca
Santini, Claudio
Melandri, Serena
Ansalone, Gerardo
Sbarbati, Stefano
Sighieri, Cinzia
Lung Ultrasound in COVID-19: Clinical Correlates and Comparison with Chest Computed Tomography
title Lung Ultrasound in COVID-19: Clinical Correlates and Comparison with Chest Computed Tomography
title_full Lung Ultrasound in COVID-19: Clinical Correlates and Comparison with Chest Computed Tomography
title_fullStr Lung Ultrasound in COVID-19: Clinical Correlates and Comparison with Chest Computed Tomography
title_full_unstemmed Lung Ultrasound in COVID-19: Clinical Correlates and Comparison with Chest Computed Tomography
title_short Lung Ultrasound in COVID-19: Clinical Correlates and Comparison with Chest Computed Tomography
title_sort lung ultrasound in covid-19: clinical correlates and comparison with chest computed tomography
topic Covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211720/
https://www.ncbi.nlm.nih.gov/pubmed/34179691
http://dx.doi.org/10.1007/s42399-021-00986-1
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