Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker

The mechanism behind transgenerational epigenetic inheritance is unclear, particularly through the maternal grandparental line. We previously showed that disruption of folate metabolism in mice by the Mtrr hypomorphic mutation results in transgenerational epigenetic inheritance of congenital malform...

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Detalles Bibliográficos
Autores principales: Blake, Georgina E. T., Zhao, Xiaohui, Yung, Hong wa, Burton, Graham J., Ferguson-Smith, Anne C., Hamilton, Russell S., Watson, Erica D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211854/
https://www.ncbi.nlm.nih.gov/pubmed/34140513
http://dx.doi.org/10.1038/s41467-021-24036-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211854/
https://www.ncbi.nlm.nih.gov/pubmed/34140513
http://dx.doi.org/10.1038/s41467-021-24036-5

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