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Surgical Diagnosis and Treatment of Primary Retroperitoneal Liposarcoma

Background: Primary retroperitoneal liposarcoma (PRPLS) is the most common soft tissue sarcoma of the retroperitoneum with high recurrence rate and short overall survival (OS). Methods: A retrospective review of 51 patients with PRPLS, treated between September 1, 2009 and November 30, 2020, was con...

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Autores principales: Chen, Jie, Hang, Ying, Gao, Qi, Huang, Xinyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211986/
https://www.ncbi.nlm.nih.gov/pubmed/34150840
http://dx.doi.org/10.3389/fsurg.2021.672669
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author Chen, Jie
Hang, Ying
Gao, Qi
Huang, Xinyu
author_facet Chen, Jie
Hang, Ying
Gao, Qi
Huang, Xinyu
author_sort Chen, Jie
collection PubMed
description Background: Primary retroperitoneal liposarcoma (PRPLS) is the most common soft tissue sarcoma of the retroperitoneum with high recurrence rate and short overall survival (OS). Methods: A retrospective review of 51 patients with PRPLS, treated between September 1, 2009 and November 30, 2020, was conducted to evaluate clinical outcomes of PRPLS resection. Patient demographics, histopathologic subtypes, overall survival (OS), progression-free survival (PFS), disease recurrence rate, and tumor stage were reviewed and analyzed. Univariate analysis was done to identify factors potentially affecting OS and PFS of PRPLS patients. Multivariate Cox proportional hazards analysis was used to evaluate the impact of various clinicopathological factors on OS and PFS of PRPLS patients. Results: Fifty-one PRPLS patients (28 Males, 23 Females; mean age 56.25 years) were evaluated. There was no significant effect of age, gender, contiguous organ resection, degree of differentiation and tumor size on the OS and PFS of the patients. Univariate analysis showed that negative surgical margin and early tumor stage significantly correlated with OS and PFS (all P < 0.001). Multivariate analysis showed that tumor stage [hazard ratio (HR) = 1.177, P = 0.001] was an independent predictors of poor progression-free survival, and surgical margins [HR = 4.0674 P = 0.038] and tumor stage [HR = 1.167 P = 0.001] were identified as independent predictors of poor overall survival. Conclusion: Negative surgical margin is a prognostic factor of OS, and can prolong the postoperative survival time of PRPLS patients. Tumor stage is a prognostic factor for OS and PFS, and can influence the survival of PRPLS patients. Earlier tumor stages of PRPLS are associated with significantly better outcomes.
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spelling pubmed-82119862021-06-19 Surgical Diagnosis and Treatment of Primary Retroperitoneal Liposarcoma Chen, Jie Hang, Ying Gao, Qi Huang, Xinyu Front Surg Surgery Background: Primary retroperitoneal liposarcoma (PRPLS) is the most common soft tissue sarcoma of the retroperitoneum with high recurrence rate and short overall survival (OS). Methods: A retrospective review of 51 patients with PRPLS, treated between September 1, 2009 and November 30, 2020, was conducted to evaluate clinical outcomes of PRPLS resection. Patient demographics, histopathologic subtypes, overall survival (OS), progression-free survival (PFS), disease recurrence rate, and tumor stage were reviewed and analyzed. Univariate analysis was done to identify factors potentially affecting OS and PFS of PRPLS patients. Multivariate Cox proportional hazards analysis was used to evaluate the impact of various clinicopathological factors on OS and PFS of PRPLS patients. Results: Fifty-one PRPLS patients (28 Males, 23 Females; mean age 56.25 years) were evaluated. There was no significant effect of age, gender, contiguous organ resection, degree of differentiation and tumor size on the OS and PFS of the patients. Univariate analysis showed that negative surgical margin and early tumor stage significantly correlated with OS and PFS (all P < 0.001). Multivariate analysis showed that tumor stage [hazard ratio (HR) = 1.177, P = 0.001] was an independent predictors of poor progression-free survival, and surgical margins [HR = 4.0674 P = 0.038] and tumor stage [HR = 1.167 P = 0.001] were identified as independent predictors of poor overall survival. Conclusion: Negative surgical margin is a prognostic factor of OS, and can prolong the postoperative survival time of PRPLS patients. Tumor stage is a prognostic factor for OS and PFS, and can influence the survival of PRPLS patients. Earlier tumor stages of PRPLS are associated with significantly better outcomes. Frontiers Media S.A. 2021-06-04 /pmc/articles/PMC8211986/ /pubmed/34150840 http://dx.doi.org/10.3389/fsurg.2021.672669 Text en Copyright © 2021 Chen, Hang, Gao and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Chen, Jie
Hang, Ying
Gao, Qi
Huang, Xinyu
Surgical Diagnosis and Treatment of Primary Retroperitoneal Liposarcoma
title Surgical Diagnosis and Treatment of Primary Retroperitoneal Liposarcoma
title_full Surgical Diagnosis and Treatment of Primary Retroperitoneal Liposarcoma
title_fullStr Surgical Diagnosis and Treatment of Primary Retroperitoneal Liposarcoma
title_full_unstemmed Surgical Diagnosis and Treatment of Primary Retroperitoneal Liposarcoma
title_short Surgical Diagnosis and Treatment of Primary Retroperitoneal Liposarcoma
title_sort surgical diagnosis and treatment of primary retroperitoneal liposarcoma
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211986/
https://www.ncbi.nlm.nih.gov/pubmed/34150840
http://dx.doi.org/10.3389/fsurg.2021.672669
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