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Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered Approach

Fifty-four consecutive persons with HIV co-infected with hepatitis C virus (HCV) and liver decompensation were treated with direct-acting antivirals (DAA). The HCV treatment was delivered using a multidisciplinary HIV-coinfection model of care integrating sub-specialty services in 3 countries. Of th...

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Autores principales: Cachay, Edward R., Mena, Alvaro, Morano, Luis, Benitez, Laura, Maida, Ivana, Mendoza, Carmen DE, Hill, Lucas, Torriani, Francesca, Soriano, Vincente, Mathews, W. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212364/
https://www.ncbi.nlm.nih.gov/pubmed/34132142
http://dx.doi.org/10.1177/23259582211024771
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author Cachay, Edward R.
Mena, Alvaro
Morano, Luis
Benitez, Laura
Maida, Ivana
Mendoza, Carmen DE
Hill, Lucas
Torriani, Francesca
Soriano, Vincente
Mathews, W. C.
author_facet Cachay, Edward R.
Mena, Alvaro
Morano, Luis
Benitez, Laura
Maida, Ivana
Mendoza, Carmen DE
Hill, Lucas
Torriani, Francesca
Soriano, Vincente
Mathews, W. C.
author_sort Cachay, Edward R.
collection PubMed
description Fifty-four consecutive persons with HIV co-infected with hepatitis C virus (HCV) and liver decompensation were treated with direct-acting antivirals (DAA). The HCV treatment was delivered using a multidisciplinary HIV-coinfection model of care integrating sub-specialty services in 3 countries. Of those treated, 91% (95% confidence interval, 80.1 to 95.9) achieved sustained viral response, and only one person died during treatment. Our study provides evidence that HIV providers achieve excellent outcomes when treating patients with histories of decompensated liver disease, with characteristics similar to those studied using a multidisciplinary HIV-centered approach.
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spelling pubmed-82123642021-06-28 Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered Approach Cachay, Edward R. Mena, Alvaro Morano, Luis Benitez, Laura Maida, Ivana Mendoza, Carmen DE Hill, Lucas Torriani, Francesca Soriano, Vincente Mathews, W. C. J Int Assoc Provid AIDS Care Original Research Article Fifty-four consecutive persons with HIV co-infected with hepatitis C virus (HCV) and liver decompensation were treated with direct-acting antivirals (DAA). The HCV treatment was delivered using a multidisciplinary HIV-coinfection model of care integrating sub-specialty services in 3 countries. Of those treated, 91% (95% confidence interval, 80.1 to 95.9) achieved sustained viral response, and only one person died during treatment. Our study provides evidence that HIV providers achieve excellent outcomes when treating patients with histories of decompensated liver disease, with characteristics similar to those studied using a multidisciplinary HIV-centered approach. SAGE Publications 2021-06-16 /pmc/articles/PMC8212364/ /pubmed/34132142 http://dx.doi.org/10.1177/23259582211024771 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Article
Cachay, Edward R.
Mena, Alvaro
Morano, Luis
Benitez, Laura
Maida, Ivana
Mendoza, Carmen DE
Hill, Lucas
Torriani, Francesca
Soriano, Vincente
Mathews, W. C.
Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered Approach
title Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered Approach
title_full Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered Approach
title_fullStr Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered Approach
title_full_unstemmed Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered Approach
title_short Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered Approach
title_sort hepatitis c treatment outcomes in persons with hiv and decompensated cirrhosis using a collaborative multidisciplinary hiv-centered approach
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212364/
https://www.ncbi.nlm.nih.gov/pubmed/34132142
http://dx.doi.org/10.1177/23259582211024771
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