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Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered Approach
Fifty-four consecutive persons with HIV co-infected with hepatitis C virus (HCV) and liver decompensation were treated with direct-acting antivirals (DAA). The HCV treatment was delivered using a multidisciplinary HIV-coinfection model of care integrating sub-specialty services in 3 countries. Of th...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212364/ https://www.ncbi.nlm.nih.gov/pubmed/34132142 http://dx.doi.org/10.1177/23259582211024771 |
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author | Cachay, Edward R. Mena, Alvaro Morano, Luis Benitez, Laura Maida, Ivana Mendoza, Carmen DE Hill, Lucas Torriani, Francesca Soriano, Vincente Mathews, W. C. |
author_facet | Cachay, Edward R. Mena, Alvaro Morano, Luis Benitez, Laura Maida, Ivana Mendoza, Carmen DE Hill, Lucas Torriani, Francesca Soriano, Vincente Mathews, W. C. |
author_sort | Cachay, Edward R. |
collection | PubMed |
description | Fifty-four consecutive persons with HIV co-infected with hepatitis C virus (HCV) and liver decompensation were treated with direct-acting antivirals (DAA). The HCV treatment was delivered using a multidisciplinary HIV-coinfection model of care integrating sub-specialty services in 3 countries. Of those treated, 91% (95% confidence interval, 80.1 to 95.9) achieved sustained viral response, and only one person died during treatment. Our study provides evidence that HIV providers achieve excellent outcomes when treating patients with histories of decompensated liver disease, with characteristics similar to those studied using a multidisciplinary HIV-centered approach. |
format | Online Article Text |
id | pubmed-8212364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-82123642021-06-28 Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered Approach Cachay, Edward R. Mena, Alvaro Morano, Luis Benitez, Laura Maida, Ivana Mendoza, Carmen DE Hill, Lucas Torriani, Francesca Soriano, Vincente Mathews, W. C. J Int Assoc Provid AIDS Care Original Research Article Fifty-four consecutive persons with HIV co-infected with hepatitis C virus (HCV) and liver decompensation were treated with direct-acting antivirals (DAA). The HCV treatment was delivered using a multidisciplinary HIV-coinfection model of care integrating sub-specialty services in 3 countries. Of those treated, 91% (95% confidence interval, 80.1 to 95.9) achieved sustained viral response, and only one person died during treatment. Our study provides evidence that HIV providers achieve excellent outcomes when treating patients with histories of decompensated liver disease, with characteristics similar to those studied using a multidisciplinary HIV-centered approach. SAGE Publications 2021-06-16 /pmc/articles/PMC8212364/ /pubmed/34132142 http://dx.doi.org/10.1177/23259582211024771 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Article Cachay, Edward R. Mena, Alvaro Morano, Luis Benitez, Laura Maida, Ivana Mendoza, Carmen DE Hill, Lucas Torriani, Francesca Soriano, Vincente Mathews, W. C. Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered Approach |
title | Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated
Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered
Approach |
title_full | Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated
Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered
Approach |
title_fullStr | Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated
Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered
Approach |
title_full_unstemmed | Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated
Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered
Approach |
title_short | Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated
Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered
Approach |
title_sort | hepatitis c treatment outcomes in persons with hiv and decompensated
cirrhosis using a collaborative multidisciplinary hiv-centered
approach |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212364/ https://www.ncbi.nlm.nih.gov/pubmed/34132142 http://dx.doi.org/10.1177/23259582211024771 |
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