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Massive PD-L1 and CD8 double positive TILs characterize an immunosuppressive microenvironment with high mutational burden in lung cancer

BACKGROUND: Programmed cell death ligand 1 (PD-L1) expressed on tumor and immune cells are both associated with the response to programmed cell death 1 (PD-1) pathway blockade therapy. Here, we examine the role of CD8+PD-L1+ tumor-infiltrating lymphocyte (Tils) in the tumor microenvironment of non-s...

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Detalles Bibliográficos
Autores principales:	Zhang, Libin, Chen, Yanhui, Wang, Han, Xu, Zheyuan, Wang, Yang, Li, Sixing, Liu, Jun, Chen, Yun, Luo, Hongli, Wu, Lijia, Yang, Ying, Zhang, Henghui, Peng, Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Immunotherapy Biomarkers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212410/ https://www.ncbi.nlm.nih.gov/pubmed/34140315 http://dx.doi.org/10.1136/jitc-2021-002356

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