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Discovery of a Highly Conserved Peptide in the Iron Transporter Melanotransferrin that Traverses an Intact Blood Brain Barrier and Localizes in Neural Cells
The blood-brain barrier (BBB) hinders the distribution of therapeutics intended for treatment of diseases of the brain. Our previous studies demonstrated that that a soluble form of melanotransferrin (MTf; Uniprot P08582; also known as p97, MFI2, and CD228), a mammalian iron-transport protein, is an...
Autores principales: | Singh, Chaahat S. B., Eyford, Brett A., Abraham, Thomas, Munro, Lonna, Choi, Kyung Bok, Okon, Mark, Vitalis, Timothy Z., Gabathuler, Reinhard, Lu, Chieh-Ju, Pfeifer, Cheryl G., Tian, Mei Mei, Jefferies, Wilfred A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212695/ https://www.ncbi.nlm.nih.gov/pubmed/34149342 http://dx.doi.org/10.3389/fnins.2021.596976 |
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