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Zika virus infection during pregnancy protects against secondary infection in the absence of CD8(+) cells
While T cell immunity is an important component of the immune response to Zika virus (ZIKV) infection generally, the efficacy of these responses during pregnancy remains unknown. Here, we tested the capacity of CD8 lymphocytes to protect from secondary challenge in four macaques, two of which were d...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212702/ https://www.ncbi.nlm.nih.gov/pubmed/33865073 http://dx.doi.org/10.1016/j.virol.2021.03.019 |
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author | Schouest, Blake Beddingfield, Brandon J. Gilbert, Margaret H. Bohm, Rudolf P. Schiro, Faith Aye, Pyone P. Panganiban, Antonito T. Magnani, Diogo M. Maness, Nicholas J. |
author_facet | Schouest, Blake Beddingfield, Brandon J. Gilbert, Margaret H. Bohm, Rudolf P. Schiro, Faith Aye, Pyone P. Panganiban, Antonito T. Magnani, Diogo M. Maness, Nicholas J. |
author_sort | Schouest, Blake |
collection | PubMed |
description | While T cell immunity is an important component of the immune response to Zika virus (ZIKV) infection generally, the efficacy of these responses during pregnancy remains unknown. Here, we tested the capacity of CD8 lymphocytes to protect from secondary challenge in four macaques, two of which were depleted of CD8(+) cells prior to rechallenge with a heterologous ZIKV isolate. The initial challenge during pregnancy produced transcriptional signatures suggesting complex patterns of immune modulation as well as neutralizing antibodies that persisted until rechallenge, which all animals efficiently controlled, demonstrating that the primary infection conferred adequate protection. The secondary challenge promoted activation of innate and adaptive immune cells, possibly suggesting a brief period of infection prior to clearance. These data confirm that ZIKV infection during pregnancy induces sufficient immunity to protect from a secondary challenge and suggest that this protection is not dependent on CD8 T cells. |
format | Online Article Text |
id | pubmed-8212702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Academic Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-82127022021-07-01 Zika virus infection during pregnancy protects against secondary infection in the absence of CD8(+) cells Schouest, Blake Beddingfield, Brandon J. Gilbert, Margaret H. Bohm, Rudolf P. Schiro, Faith Aye, Pyone P. Panganiban, Antonito T. Magnani, Diogo M. Maness, Nicholas J. Virology Article While T cell immunity is an important component of the immune response to Zika virus (ZIKV) infection generally, the efficacy of these responses during pregnancy remains unknown. Here, we tested the capacity of CD8 lymphocytes to protect from secondary challenge in four macaques, two of which were depleted of CD8(+) cells prior to rechallenge with a heterologous ZIKV isolate. The initial challenge during pregnancy produced transcriptional signatures suggesting complex patterns of immune modulation as well as neutralizing antibodies that persisted until rechallenge, which all animals efficiently controlled, demonstrating that the primary infection conferred adequate protection. The secondary challenge promoted activation of innate and adaptive immune cells, possibly suggesting a brief period of infection prior to clearance. These data confirm that ZIKV infection during pregnancy induces sufficient immunity to protect from a secondary challenge and suggest that this protection is not dependent on CD8 T cells. Academic Press 2021-07 /pmc/articles/PMC8212702/ /pubmed/33865073 http://dx.doi.org/10.1016/j.virol.2021.03.019 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Schouest, Blake Beddingfield, Brandon J. Gilbert, Margaret H. Bohm, Rudolf P. Schiro, Faith Aye, Pyone P. Panganiban, Antonito T. Magnani, Diogo M. Maness, Nicholas J. Zika virus infection during pregnancy protects against secondary infection in the absence of CD8(+) cells |
title | Zika virus infection during pregnancy protects against secondary infection in the absence of CD8(+) cells |
title_full | Zika virus infection during pregnancy protects against secondary infection in the absence of CD8(+) cells |
title_fullStr | Zika virus infection during pregnancy protects against secondary infection in the absence of CD8(+) cells |
title_full_unstemmed | Zika virus infection during pregnancy protects against secondary infection in the absence of CD8(+) cells |
title_short | Zika virus infection during pregnancy protects against secondary infection in the absence of CD8(+) cells |
title_sort | zika virus infection during pregnancy protects against secondary infection in the absence of cd8(+) cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212702/ https://www.ncbi.nlm.nih.gov/pubmed/33865073 http://dx.doi.org/10.1016/j.virol.2021.03.019 |
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