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Altered vitamin A metabolism in human liver slices corresponds to fibrogenesis
ABSTRACT: All‐trans‐retinoic acid (atRA), the active metabolite of vitamin A, has antifibrogenic properties in vitro and in animal models. Liver vitamin A homeostasis is maintained by cell‐specific enzymatic activities including storage in hepatic stellate cells (HSCs), secretion into circulation fr...
Autores principales: | Czuba, Lindsay C., Wu, Xia, Huang, Weize, Hollingshead, Nicole, Roberto, Jessica B., Kenerson, Heidi L., Yeung, Raymond S., Crispe, Ian N., Isoherranen, Nina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212748/ https://www.ncbi.nlm.nih.gov/pubmed/33382909 http://dx.doi.org/10.1111/cts.12962 |
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