Cargando…

Haem is crucial for medium-dependent metronidazole resistance in clinical isolates of Clostridioides difficile

BACKGROUND: Until recently, metronidazole was the first-line treatment for Clostridioides difficile infection and it is still commonly used. Though resistance has been reported due to the plasmid pCD-METRO, this does not explain all cases. OBJECTIVES: To identify factors that contribute to plasmid-i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Boekhoud, Ilse M, Sidorov, Igor, Nooij, Sam, Harmanus, Céline, Bos-Sanders, Ingrid M J G, Viprey, Virginie, Spittal, William, Clark, Emma, Davies, Kerrie, Freeman, Jane, Kuijper, Ed J, Smits, Wiep Klaas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212768/ https://www.ncbi.nlm.nih.gov/pubmed/33876817 http://dx.doi.org/10.1093/jac/dkab097

Ejemplares similares

Plasmid-mediated metronidazole resistance in Clostridioides difficile
por: Boekhoud, Ilse M., et al.
Publicado: (2020)

Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates
por: Smits, Wiep Klaas, et al.
Publicado: (2022)

An in silico survey of Clostridioides difficile extrachromosomal elements
por: Hornung, Bastian V. H., et al.
Publicado: (2019)

Host Immune Responses to Clostridioides difficile: Toxins and Beyond
por: Nibbering, Britt, et al.
Publicado: (2021)

Redefining the Clostridioides difficile σ(B) Regulon: σ(B) Activates Genes Involved in Detoxifying Radicals That Can Result from the Exposure to Antimicrobials and Hydrogen Peroxide
por: Boekhoud, Ilse M., et al.
Publicado: (2020)

The vanR(Cd) Mutation 343A>G, Resulting in a Thr115Ala Substitution, Is Associated with an Elevated Minimum Inhibitory Concentration (MIC) of Vancomycin in Clostridioides difficile Clinical Isolates from Florida
por: Wickramage, Ishani, et al.
Publicado: (2023)

2’-Fucosyllactose inhibits proliferation of Clostridioides difficile ATCC 43599 in the CDi-screen, an in vitro model simulating Clostridioides difficile infection
por: Wiese, Maria, et al.
Publicado: (2022)

TcdC Does Not Significantly Repress Toxin Expression in Clostridium difficile 630ΔErm
por: Bakker, Dennis, et al.
Publicado: (2012)

Quantification of Clostridioides (Clostridium) difficile in feces of calves of different age and determination of predominant Clostridioides difficile ribotype 033 relatedness and transmission between family dairy farms using multilocus variable-number tandem-repeat analysis
por: Bandelj, Petra, et al.
Publicado: (2018)

Identification of the Unwinding Region in the Clostridioides difficile Chromosomal Origin of Replication
por: Oliveira Paiva, Ana M., et al.
Publicado: (2020)

Non-Toxigenic Clostridioides difficile Strain E4 (NTCD-E4) Prevents Establishment of Primary C. difficile Infection by Epidemic PCR Ribotype 027 in an In Vitro Human Gut Model
por: Etifa, Perezimor, et al.
Publicado: (2023)

Antibiotic Resistance Profile of RT 027/176 Versus Other Clostridioides difficile Isolates in Silesia, Southern Poland
por: Aptekorz, Małgorzata, et al.
Publicado: (2022)

C. difficile 630Δerm Spo0A Regulates Sporulation, but Does Not Contribute to Toxin Production, by Direct High-Affinity Binding to Target DNA
por: Rosenbusch, Katharina E., et al.
Publicado: (2012)

Community-Onset Clostridioides Difficile Infection in Hospitalized Patients in The Netherlands
por: Crobach, M J T, et al.
Publicado: (2019)

The Bacterial Gut Microbiota of Adult Patients Infected, Colonized or Noncolonized by Clostridioides difficile
por: Crobach, Monique J. T., et al.
Publicado: (2020)

Clostridioides difficile Ribotype 027 (RT027) Outbreak Investigation Due to the Emergence of Rifampicin Resistance Using Multilocus Variable-Number Tandem Repeat Analysis (MLVA)
por: Kabała, Monika, et al.
Publicado: (2021)

Clostridioides difficile Phosphoproteomics Shows an Expansion of Phosphorylated Proteins in Stationary Growth Phase
por: Smits, Wiep Klaas, et al.
Publicado: (2022)

Clostridioides difficile positivity rate and PCR ribotype distribution on retail potatoes in 12 European countries, January to June 2018
por: Tkalec, Valerija, et al.
Publicado: (2022)

Hype or hypervirulence: A reflection on problematic C. difficile strains
por: Smits, Wiep Klaas
Publicado: (2013)

In-Depth Characterization of the Clostridioides difficile Phosphoproteome to Identify Ser/Thr Kinase Substrates
por: Garcia-Garcia, Transito, et al.
Publicado: (2022)

Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections
por: Baktash, Amoe, et al.
Publicado: (2018)

Characterization of the virulence of a non-RT027, non-RT078 and binary toxin-positive Clostridium difficile strain associated with severe diarrhea
por: Li, Chunhui, et al.
Publicado: (2018)

SNP-ing out the differences: Investigating differences between Clostridium difficile lab strains
por: Smits, Wiep Klaas
Publicado: (2016)

A point-prevalence study on community and inpatient Clostridioides difficile infections (CDI): results from Combatting Bacterial Resistance in Europe CDI (COMBACTE-CDI), July to November 2018
por: Viprey, Virginie F, et al.
Publicado: (2022)

Reduced Susceptibility to Metronidazole Is Associated With Initial Clinical Failure in Clostridioides difficile Infection
por: Gonzales-Luna, Anne J, et al.
Publicado: (2021)

Detection of Plasmid-Mediated Resistance to Metronidazole in Clostridioides difficile from River Water
por: Cizek, Alois, et al.
Publicado: (2022)

New insights into the type A glycan modification of Clostridioides difficile flagellar protein flagellin C by phosphoproteomics analysis
por: Hensbergen, Paul J., et al.
Publicado: (2022)

Comparison of trends in Clostridioides difficile infections in hospitalised patients during the first and second waves of the COVID-19 pandemic: A retrospective sentinel surveillance study
por: Vendrik, Karuna E.W., et al.
Publicado: (2022)

710. Increased Clinical Failure Rates Associated with Reduced Metronidazole Susceptibility in Clostridioides difficile
por: Gonzales-Luna, Anne, et al.
Publicado: (2018)

Impact of subinhibitory concentrations of metronidazole on proteome of Clostridioides difficile strains with different levels of susceptibility
por: Doan, Tri-Hanh-Dung, et al.
Publicado: (2020)

840. Clinical Failure Rates Associated with Hemin-induced Metronidazole Resistance in Clostridioides difficile
por: Gonzales-Luna, Anne J, et al.
Publicado: (2019)

Impact of Subinhibitory Concentrations of Metronidazole on Morphology, Motility, Biofilm Formation and Colonization of Clostridioides difficile
por: Doan, Tri-Hanh-Dung, et al.
Publicado: (2022)

Which is the Preferred Regimen for Non-Severe Clostridioides difficile Infection in Korea, Vancomycin or Metronidazole?
por: Kim, Jieun, et al.
Publicado: (2022)

DNA replication proteins as potential targets for antimicrobials in drug-resistant bacterial pathogens
por: van Eijk, Erika, et al.
Publicado: (2017)

Effect of sub-MIC values of metronidazole, ciprofloxacin, and imipenem on the growth and toxin production in Clostridioides difficile
por: Shayegan Mehr, Farahnaz Sadat, et al.
Publicado: (2019)

Efficacy of Bezlotoxumab in Participants Receiving Metronidazole, Vancomycin, or Fidaxomicin for Treatment of Clostridioides (Clostridium) difficile Infection
por: Dubberke, Erik R, et al.
Publicado: (2020)

Initial vancomycin versus metronidazole for the treatment of first-episode non-severe Clostridioides difficile infection
por: Zhang, Kevin, et al.
Publicado: (2021)

Typing Clostridium difficile strains based on tandem repeat sequences
por: Zaiß, N Henning, et al.
Publicado: (2009)

Evaluation of the Liat Cdiff Assay for Direct Detection of Clostridioides difficile Toxin Genes within 20 Minutes
por: Hetem, David J., et al.
Publicado: (2019)

2433. Oral Vancomycin Plus Intravenous Metronidazole for Severe Clostridioides difficile Infection in Critically Ill Patients
por: Vega, Ana D, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_f58rfr1jvld9n94jq52l3rhhr4