Inhibiting BRD4 to generate BETter T cell memory

BRD4 is a bromodomain-containing protein that binds acetylated histones to regulate transcription. In this issue of JEM, Milner et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20202512) show that BRD4 plays a critical role in the effector function of CD8 T cells responding to infection and ca...

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Detalles Bibliográficos
Autores principales: Kasmani, Moujtaba Y., Cui, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212782/
https://www.ncbi.nlm.nih.gov/pubmed/34132742
http://dx.doi.org/10.1084/jem.20210877
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author Kasmani, Moujtaba Y.
Cui, Weiguo
author_facet Kasmani, Moujtaba Y.
Cui, Weiguo
author_sort Kasmani, Moujtaba Y.
collection PubMed
description BRD4 is a bromodomain-containing protein that binds acetylated histones to regulate transcription. In this issue of JEM, Milner et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20202512) show that BRD4 plays a critical role in the effector function of CD8 T cells responding to infection and cancer.
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spelling pubmed-82127822022-02-02 Inhibiting BRD4 to generate BETter T cell memory Kasmani, Moujtaba Y. Cui, Weiguo J Exp Med Insights BRD4 is a bromodomain-containing protein that binds acetylated histones to regulate transcription. In this issue of JEM, Milner et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20202512) show that BRD4 plays a critical role in the effector function of CD8 T cells responding to infection and cancer. Rockefeller University Press 2021-06-16 /pmc/articles/PMC8212782/ /pubmed/34132742 http://dx.doi.org/10.1084/jem.20210877 Text en © 2021 Kasmani and Cui http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Kasmani, Moujtaba Y.
Cui, Weiguo
Inhibiting BRD4 to generate BETter T cell memory
title Inhibiting BRD4 to generate BETter T cell memory
title_full Inhibiting BRD4 to generate BETter T cell memory
title_fullStr Inhibiting BRD4 to generate BETter T cell memory
title_full_unstemmed Inhibiting BRD4 to generate BETter T cell memory
title_short Inhibiting BRD4 to generate BETter T cell memory
title_sort inhibiting brd4 to generate better t cell memory
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212782/
https://www.ncbi.nlm.nih.gov/pubmed/34132742
http://dx.doi.org/10.1084/jem.20210877
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AT cuiweiguo inhibitingbrd4togeneratebettertcellmemory

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