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A new nairo-like virus associated with human febrile illness in China

Several nairo-like viruses have been discovered in ticks in recent years, but their relevance to public health remains unknown. Here, we found a patient who had a history of tick bite and suffered from a febrile illness was infected with a previously discovered RNA virus, Beiji nairovirus (BJNV), in...

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Autores principales: Wang, Yan-Chun, Wei, Zhengkai, Lv, Xiaolong, Han, Shuzheng, Wang, Zedong, Fan, Changfa, Zhang, Xu, Shao, Jianwei, Zhao, Ying-Hua, Sui, Liyan, Chen, Chen, Liao, Ming, Wang, Bo, Jin, Ningyi, Li, Chang, Ma, Jun, Hou, Zhi-Jun, Yang, Zhengtao, Han, Zhen, Zhang, Yong, Niu, Junqi, Wang, Wei, Wang, Youchun, Liu, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212832/
https://www.ncbi.nlm.nih.gov/pubmed/34044749
http://dx.doi.org/10.1080/22221751.2021.1936197
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author Wang, Yan-Chun
Wei, Zhengkai
Lv, Xiaolong
Han, Shuzheng
Wang, Zedong
Fan, Changfa
Zhang, Xu
Shao, Jianwei
Zhao, Ying-Hua
Sui, Liyan
Chen, Chen
Liao, Ming
Wang, Bo
Jin, Ningyi
Li, Chang
Ma, Jun
Hou, Zhi-Jun
Yang, Zhengtao
Han, Zhen
Zhang, Yong
Niu, Junqi
Wang, Wei
Wang, Youchun
Liu, Quan
author_facet Wang, Yan-Chun
Wei, Zhengkai
Lv, Xiaolong
Han, Shuzheng
Wang, Zedong
Fan, Changfa
Zhang, Xu
Shao, Jianwei
Zhao, Ying-Hua
Sui, Liyan
Chen, Chen
Liao, Ming
Wang, Bo
Jin, Ningyi
Li, Chang
Ma, Jun
Hou, Zhi-Jun
Yang, Zhengtao
Han, Zhen
Zhang, Yong
Niu, Junqi
Wang, Wei
Wang, Youchun
Liu, Quan
author_sort Wang, Yan-Chun
collection PubMed
description Several nairo-like viruses have been discovered in ticks in recent years, but their relevance to public health remains unknown. Here, we found a patient who had a history of tick bite and suffered from a febrile illness was infected with a previously discovered RNA virus, Beiji nairovirus (BJNV), in the nairo-like virus group of the order Bunyavirales. We isolated the virus by cell culture assay. BJNV could induce cytopathic effects in the baby hamster kidney and human hepatocellular carcinoma cells. Negative-stain electron microscopy revealed enveloped and spherical viral particles, morphologically similar to those of nairoviruses. We identified 67 patients as BJNV infection in 2017–2018. The median age of patients was 48 years (interquartile range 41–53 years); the median incubation period was 7 days (interquartile range 3–12 days). Most patients were men (70%), and a few (10%) had underlying diseases. Common symptoms of infected patients included fever (100%), headache (99%), depression (63%), coma (63%), and fatigue (54%), myalgia or arthralgia (45%); two (3%) patients became critically ill and one died. BJNV could cause growth retardation, viremia and histopathological changes in infected suckling mice. BJNV was also detected in sheep, cattle, and multiple tick species. These findings demonstrated that the newly discovered nairo-like virus may be associated with a febrile illness, with the potential vectors of ticks and reservoirs of sheep and cattle, highlighting its public health significance and necessity of further investigation in the tick-endemic areas worldwide.
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spelling pubmed-82128322021-06-28 A new nairo-like virus associated with human febrile illness in China Wang, Yan-Chun Wei, Zhengkai Lv, Xiaolong Han, Shuzheng Wang, Zedong Fan, Changfa Zhang, Xu Shao, Jianwei Zhao, Ying-Hua Sui, Liyan Chen, Chen Liao, Ming Wang, Bo Jin, Ningyi Li, Chang Ma, Jun Hou, Zhi-Jun Yang, Zhengtao Han, Zhen Zhang, Yong Niu, Junqi Wang, Wei Wang, Youchun Liu, Quan Emerg Microbes Infect Research Article Several nairo-like viruses have been discovered in ticks in recent years, but their relevance to public health remains unknown. Here, we found a patient who had a history of tick bite and suffered from a febrile illness was infected with a previously discovered RNA virus, Beiji nairovirus (BJNV), in the nairo-like virus group of the order Bunyavirales. We isolated the virus by cell culture assay. BJNV could induce cytopathic effects in the baby hamster kidney and human hepatocellular carcinoma cells. Negative-stain electron microscopy revealed enveloped and spherical viral particles, morphologically similar to those of nairoviruses. We identified 67 patients as BJNV infection in 2017–2018. The median age of patients was 48 years (interquartile range 41–53 years); the median incubation period was 7 days (interquartile range 3–12 days). Most patients were men (70%), and a few (10%) had underlying diseases. Common symptoms of infected patients included fever (100%), headache (99%), depression (63%), coma (63%), and fatigue (54%), myalgia or arthralgia (45%); two (3%) patients became critically ill and one died. BJNV could cause growth retardation, viremia and histopathological changes in infected suckling mice. BJNV was also detected in sheep, cattle, and multiple tick species. These findings demonstrated that the newly discovered nairo-like virus may be associated with a febrile illness, with the potential vectors of ticks and reservoirs of sheep and cattle, highlighting its public health significance and necessity of further investigation in the tick-endemic areas worldwide. Taylor & Francis 2021-06-17 /pmc/articles/PMC8212832/ /pubmed/34044749 http://dx.doi.org/10.1080/22221751.2021.1936197 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Yan-Chun
Wei, Zhengkai
Lv, Xiaolong
Han, Shuzheng
Wang, Zedong
Fan, Changfa
Zhang, Xu
Shao, Jianwei
Zhao, Ying-Hua
Sui, Liyan
Chen, Chen
Liao, Ming
Wang, Bo
Jin, Ningyi
Li, Chang
Ma, Jun
Hou, Zhi-Jun
Yang, Zhengtao
Han, Zhen
Zhang, Yong
Niu, Junqi
Wang, Wei
Wang, Youchun
Liu, Quan
A new nairo-like virus associated with human febrile illness in China
title A new nairo-like virus associated with human febrile illness in China
title_full A new nairo-like virus associated with human febrile illness in China
title_fullStr A new nairo-like virus associated with human febrile illness in China
title_full_unstemmed A new nairo-like virus associated with human febrile illness in China
title_short A new nairo-like virus associated with human febrile illness in China
title_sort new nairo-like virus associated with human febrile illness in china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212832/
https://www.ncbi.nlm.nih.gov/pubmed/34044749
http://dx.doi.org/10.1080/22221751.2021.1936197
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