Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease: PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development

Vein graft failure remains a common clinical challenge. We applied a systems approach in mouse experiments to discover therapeutic targets for vein graft failure. METHODS: Global proteomics and high-dimensional clustering on multiple vein graft tissues were used to identify potential pathogenic mech...

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Detalles Bibliográficos
Autores principales: Decano, Julius L., Singh, Sasha A., Gasparotto Bueno, Cauê, Ho Lee, Lang, Halu, Arda, Chelvanambi, Sarvesh, Matamalas, Joan T., Zhang, Hengmin, Mlynarchik, Andrew K., Qiao, Jiao, Sharma, Amitabh, Mukai, Shin, Wang, Jianguo, Anderson, Daniel G., Ozaki, C. Keith, Libby, Peter, Aikawa, Elena, Aikawa, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212880/
https://www.ncbi.nlm.nih.gov/pubmed/33821665
http://dx.doi.org/10.1161/CIRCULATIONAHA.119.043724

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