Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases

Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q(10)-dependent pathway. Recent studies demonstrate that ferroptosis is associate...

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Autores principales: Tan, Qingyun, Fang, Yuying, Gu, Qiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213017/
https://www.ncbi.nlm.nih.gov/pubmed/34149412
http://dx.doi.org/10.3389/fphar.2021.657033
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author Tan, Qingyun
Fang, Yuying
Gu, Qiong
author_facet Tan, Qingyun
Fang, Yuying
Gu, Qiong
author_sort Tan, Qingyun
collection PubMed
description Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q(10)-dependent pathway. Recent studies demonstrate that ferroptosis is associated with central nervous system (CNS) diseases, such as stroke, Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. This review summarizes the key regulatory mechanisms of ferroptosis and its role in CNS diseases. These updates may provide novel perspective for the development of therapeutical agents against CNS diseases.
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spelling pubmed-82130172021-06-19 Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases Tan, Qingyun Fang, Yuying Gu, Qiong Front Pharmacol Pharmacology Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q(10)-dependent pathway. Recent studies demonstrate that ferroptosis is associated with central nervous system (CNS) diseases, such as stroke, Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. This review summarizes the key regulatory mechanisms of ferroptosis and its role in CNS diseases. These updates may provide novel perspective for the development of therapeutical agents against CNS diseases. Frontiers Media S.A. 2021-06-04 /pmc/articles/PMC8213017/ /pubmed/34149412 http://dx.doi.org/10.3389/fphar.2021.657033 Text en Copyright © 2021 Tan, Fang and Gu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Tan, Qingyun
Fang, Yuying
Gu, Qiong
Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
title Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
title_full Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
title_fullStr Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
title_full_unstemmed Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
title_short Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
title_sort mechanisms of modulation of ferroptosis and its role in central nervous system diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213017/
https://www.ncbi.nlm.nih.gov/pubmed/34149412
http://dx.doi.org/10.3389/fphar.2021.657033
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