IFN-β Acts on Monocytes to Ameliorate CNS Autoimmunity by Inhibiting Proinflammatory Cross-Talk Between Monocytes and Th Cells

IFN-β has been the treatment for multiple sclerosis (MS) for almost three decades, but understanding the mechanisms underlying its beneficial effects remains incomplete. We have shown that MS patients have increased numbers of GM-CSF(+) Th cells in circulation, and that IFN-β therapy reduces their n...

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Detalles Bibliográficos
Autores principales: Rasouli, Javad, Casella, Giacomo, Ishikawa, Larissa L. W., Thome, Rodolfo, Boehm, Alexandra, Ertel, Adam, Melo-Silva, Carolina R., Mari, Elisabeth R., Porazzi, Patrizia, Zhang, Weifeng, Xiao, Dan, Sigal, Luis J., Fortina, Paolo, Zhang, Guang-Xian, Rostami, Abdolmohamad, Ciric, Bogoljub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213026/
https://www.ncbi.nlm.nih.gov/pubmed/34149716
http://dx.doi.org/10.3389/fimmu.2021.679498

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