Cargando…

Low Infiltration of CD8+ PD-L1+ T Cells and M2 Macrophages Predicts Improved Clinical Outcomes After Immune Checkpoint Inhibitor Therapy in Non-Small Cell Lung Carcinoma

BACKGROUND: Many clinical studies have shown that patients with non-small cell lung carcinoma (NSCLC) can benefit from immune checkpoint inhibitor (ICI) therapy; however, PD-L1 and tumor mutation burden (TMB), which are recommended by the NCCN guidelines, are still insufficient in predicting the res...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Liuning, Lu, Guojie, Liu, Yang, Gong, Longlong, Zheng, Xue, Zheng, Hongbo, Gu, Weiguang, Yang, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213070/ https://www.ncbi.nlm.nih.gov/pubmed/34150625 http://dx.doi.org/10.3389/fonc.2021.658690

Ejemplares similares

Tumor-Infiltrating PD-1(hi)CD8(+)-T-Cell Signature as an Effective Biomarker for Immune Checkpoint Inhibitor Therapy Response Across Multiple Cancers
por: Yang, Zhenyu, et al.
Publicado: (2021)

Estrogen Receptor Downregulates Expression of PD-1/PD-L1 and Infiltration of CD8(+) T Cells by Inhibiting IL-17 Signaling Transduction in Breast Cancer
por: Shuai, Chong, et al.
Publicado: (2020)

Clinical and Prognostic Significance of Tumor-Infiltrating CD8+ T Cells and PD-L1 Expression in Primary Gastrointestinal Stromal Tumors
por: Sun, Xiangfei, et al.
Publicado: (2021)

MXRA8 is an immune-relative prognostic biomarker associated with metastasis and CD8(+) T cell infiltration in colorectal cancer
por: Tan, Lulu, et al.
Publicado: (2023)

PD-1/PD-L1 Axis, Rather Than High-Mobility Group Alarmins or CD8+ Tumor-Infiltrating Lymphocytes, Is Associated With Survival in Head and Neck Squamous Cell Carcinoma Patients Who Received Surgical Resection
por: Yang, Fan, et al.
Publicado: (2018)

Restored CD8(+)PD-1(+) T Cells Facilitate the Response to Anti-PD-1 for Patients With Pancreatic Ductal Adenocarcinoma
por: Zhu, Qian, et al.
Publicado: (2022)

Clinical Relevance of PD-L1 Expression and CD8+ T Cells’ Infiltration in Patients With Lung Invasive Mucinous Adenocarcinoma
por: Xu, Xiaoling, et al.
Publicado: (2021)

Tumor-Infiltrating CD8+ T Cells Driven by the Immune Checkpoint-Associated Gene IDO1 Are Associated With Cervical Cancer Prognosis
por: Zhang, Shun, et al.
Publicado: (2021)

Intra-Tumoral CD8+ T-Cell Infiltration and PD-L1 Positivity in Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma
por: Golesworthy, Bryn, et al.
Publicado: (2022)

PD-1 Expression Status on CD8+ Tumour Infiltrating Lymphocytes Associates With Survival in Cervical Cancer
por: Fan, Peiwen, et al.
Publicado: (2021)

Extremely high infiltration of CD8(+)PD-L1(+) cells detected in a stage III non-small cell lung cancer patient exhibiting hyperprogression during anti-PD-L1 immunotherapy after chemoradiation: A case report
por: Wu, Changshun, et al.
Publicado: (2022)

Decreased CD8(+) Lymphocytic Infiltration in Multifocal and Multicentric Glioblastomas
por: Wang, Run, et al.
Publicado: (2021)

PD-1 and TIGIT Are Highly Co-Expressed on CD8(+) T Cells in AML Patient Bone Marrow
por: Xu, Ling, et al.
Publicado: (2021)

Identification of CD8+ T cell infiltration-related genes and their prognostic values in cervical cancer
por: Shen, Xiaopeng, et al.
Publicado: (2022)

Therapeutic Targeting of the Macrophage Immune Checkpoint CD47 in Myeloid Malignancies
por: Chao, Mark P., et al.
Publicado: (2020)

Identification of Key Genes Related to CD8+ T-Cell Infiltration as Prognostic Biomarkers for Lung Adenocarcinoma
por: Du, Minjun, et al.
Publicado: (2021)

ACSL4 Expression Is Associated With CD8+ T Cell Infiltration and Immune Response in Bladder Cancer
por: Luo, Wenjie, et al.
Publicado: (2021)

PD-1(+) IFN-γ(+) subset of CD8(+) T cell in circulation predicts response to anti–PD-1 therapy in NSCLC
por: Chen, Wenxiu, et al.
Publicado: (2023)

Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8(+) T cell function
por: Petty, Amy J., et al.
Publicado: (2021)

Integrated single cell and bulk sequencing analysis identifies tumor reactive CXCR6(+) CD8 T cells as a predictor of immune infiltration and immunotherapy outcomes in hepatocellular carcinoma
por: Li, Xiaogang, et al.
Publicado: (2023)

M2 subtype tumor associated macrophages (M2-TAMs) infiltration predicts poor response rate of immune checkpoint inhibitors treatment for prostate cancer
por: JiaWei, Zhou, et al.
Publicado: (2021)

Norepinephrine inhibits CD8(+) T-cell infiltration and function, inducing anti-PD-1 mAb resistance in lung adenocarcinoma
por: Geng, Qishun, et al.
Publicado: (2023)

LMO7-ALK Fusion in a Lung Adenocarcinoma Patient With Crizotinib: A Case Report
por: Yang, Yanlong, et al.
Publicado: (2022)

Tumor-Infiltrating Cytotoxic T Cells and Tumor-Associated Macrophages Correlate With the Outcomes of Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer
por: Yang, Yuqin, et al.
Publicado: (2021)

A cuproptosis-related genes signature associated with prognosis and immune cell infiltration in osteosarcoma
por: Yang, Weiguang, et al.
Publicado: (2022)

Merkel Cell Polyoma Viral Load and Intratumoral CD8+ Lymphocyte Infiltration Predict Overall Survival in Patients With Merkel Cell Carcinoma
por: von der Grün, Jens, et al.
Publicado: (2019)

Epigenetic Silencing of Immune-Checkpoint Receptors in Bone Marrow- Infiltrating T Cells in Acute Myeloid Leukemia
por: Radpour, Ramin, et al.
Publicado: (2021)

XGBoost Classifier Based on Computed Tomography Radiomics for Prediction of Tumor-Infiltrating CD8(+) T-Cells in Patients With Pancreatic Ductal Adenocarcinoma
por: Li, Jing, et al.
Publicado: (2021)

Pro-Tumorigenic Macrophage Infiltration in Oral Squamous Cell Carcinoma and Possible Macrophage-Aimed Therapeutic Interventions
por: Bruna, Flavia, et al.
Publicado: (2021)

BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer
por: Feng, Mei, et al.
Publicado: (2021)

Enrichment of Inflammatory IL-17 and TNF-α Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1
por: Dunne, Margaret R., et al.
Publicado: (2016)

Prognostic significance of PD-L1 expression and CD8+ T cell infiltration in pulmonary neuroendocrine tumors
por: Wang, Haiyue, et al.
Publicado: (2018)

A Novel Computational Framework for Predicting the Survival of Cancer Patients With PD-1/PD-L1 Checkpoint Blockade Therapy
por: Su, Xiaofan, et al.
Publicado: (2022)

PLK4 initiates crosstalk between cell cycle, cell proliferation and macrophages infiltration in gliomas
por: Zhang, Xiaoyang, et al.
Publicado: (2022)

CD8 Positive T Lymphocyte Infiltration of Liver Metastases of Uveal Melanoma: A Case Report
por: Takahashi, Naoki, et al.
Publicado: (2021)

PD-1 does not mark tumor-infiltrating CD8+ T cell dysfunction in human gastric cancer
por: Shen, Yang, et al.
Publicado: (2020)

Alphataxin, a Small-Molecule Drug That Elevates Tumor-Infiltrating CD4(+) T Cells, in Combination With Anti-PD-1 Therapy, Suppresses Murine Renal Cancer and Metastasis
por: Bristow, Cynthia L., et al.
Publicado: (2021)

A Tumor-Infiltration CD8+ T Cell-Based Gene Signature for Facilitating the Prognosis and Estimation of Immunization Responses in HPV+ Head and Neck Squamous Cell Cancer
por: Wu, Yingning, et al.
Publicado: (2021)

The Identification of a Tumor Infiltration CD8+ T-Cell Gene Signature That Can Potentially Improve the Prognosis and Prediction of Immunization Responses in Papillary Renal Cell Carcinoma
por: Wang, Jie, et al.
Publicado: (2021)

CD8+ T Cell Co-Expressed Genes Correlate With Clinical Phenotype and Microenvironments of Urothelial Cancer
por: Wang, Yutao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ljkmsq7hjjjid7esi1flh6oae7