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High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa
As part of the human papillomavirus (HPV) vaccination strategy in South Africa, it is essential to have information on HPV prevalence, and HPV types distribution among the unvaccinated population. Information on the prevalence of HPV and the distribution of HPV types in adolescents and young women i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213156/ https://www.ncbi.nlm.nih.gov/pubmed/34143816 http://dx.doi.org/10.1371/journal.pone.0253074 |
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author | Mbulawa, Zizipho Z. A. Somdyala, Nontuthuzelo I. Mabunda, Sikhumbuzo A. Williamson, Anna-Lise |
author_facet | Mbulawa, Zizipho Z. A. Somdyala, Nontuthuzelo I. Mabunda, Sikhumbuzo A. Williamson, Anna-Lise |
author_sort | Mbulawa, Zizipho Z. A. |
collection | PubMed |
description | As part of the human papillomavirus (HPV) vaccination strategy in South Africa, it is essential to have information on HPV prevalence, and HPV types distribution among the unvaccinated population. Information on the prevalence of HPV and the distribution of HPV types in adolescents and young women in South Africa’s Eastern Cape Province is minimal. Therefore, this study investigates the prevalence, distribution of HPV types, and factors associated with HPV infection amongst unvaccinated female learners. A sample composed of 213 sexually active female learners attending high schools in the Eastern Cape Province of South Africa; median age 18 years, who provided self-collected vaginal specimens. Roche Linear Array HPV genotyping assay that detects 37 HPV genotypes was used to detect HPV infection. HPV infection was detected in 76.06% (162/213) of participants. Of these 14.55% (31/213) were positive for HPV types targeted by the Cervarix® HPV vaccine (HPV-16 and/or 18), 20.66% (44/213) by Gardasil®4 (HPV-6, -11, -16 and/or -18) and 37.09% (79/213) by Gardasil®9 (HPV-6, -11, -16, -18, -31, -33, -45, -52 and/or -58). HPV-35, commonly detected in cervical cancer cases among women of African ancestry, was frequently detected (9.40%). Participants who reported to have ever consumed alcohol had a significantly higher risk of HPV infection (OR: 2.91, 95% CI: 1.38–6.11, p = 0.005). High HPV prevalence was observed among participants. The high prevalence of HPV types targeted by the Gardasil®9 vaccine encourages the introduction of the Gardasil®9 vaccine. Data from this study will inform both vaccination campaigns and monitor the impact on HPV types after vaccination. |
format | Online Article Text |
id | pubmed-8213156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-82131562021-06-29 High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa Mbulawa, Zizipho Z. A. Somdyala, Nontuthuzelo I. Mabunda, Sikhumbuzo A. Williamson, Anna-Lise PLoS One Research Article As part of the human papillomavirus (HPV) vaccination strategy in South Africa, it is essential to have information on HPV prevalence, and HPV types distribution among the unvaccinated population. Information on the prevalence of HPV and the distribution of HPV types in adolescents and young women in South Africa’s Eastern Cape Province is minimal. Therefore, this study investigates the prevalence, distribution of HPV types, and factors associated with HPV infection amongst unvaccinated female learners. A sample composed of 213 sexually active female learners attending high schools in the Eastern Cape Province of South Africa; median age 18 years, who provided self-collected vaginal specimens. Roche Linear Array HPV genotyping assay that detects 37 HPV genotypes was used to detect HPV infection. HPV infection was detected in 76.06% (162/213) of participants. Of these 14.55% (31/213) were positive for HPV types targeted by the Cervarix® HPV vaccine (HPV-16 and/or 18), 20.66% (44/213) by Gardasil®4 (HPV-6, -11, -16 and/or -18) and 37.09% (79/213) by Gardasil®9 (HPV-6, -11, -16, -18, -31, -33, -45, -52 and/or -58). HPV-35, commonly detected in cervical cancer cases among women of African ancestry, was frequently detected (9.40%). Participants who reported to have ever consumed alcohol had a significantly higher risk of HPV infection (OR: 2.91, 95% CI: 1.38–6.11, p = 0.005). High HPV prevalence was observed among participants. The high prevalence of HPV types targeted by the Gardasil®9 vaccine encourages the introduction of the Gardasil®9 vaccine. Data from this study will inform both vaccination campaigns and monitor the impact on HPV types after vaccination. Public Library of Science 2021-06-18 /pmc/articles/PMC8213156/ /pubmed/34143816 http://dx.doi.org/10.1371/journal.pone.0253074 Text en © 2021 Mbulawa et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Mbulawa, Zizipho Z. A. Somdyala, Nontuthuzelo I. Mabunda, Sikhumbuzo A. Williamson, Anna-Lise High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa |
title | High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa |
title_full | High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa |
title_fullStr | High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa |
title_full_unstemmed | High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa |
title_short | High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa |
title_sort | high human papillomavirus prevalence among females attending high school in the eastern cape province of south africa |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213156/ https://www.ncbi.nlm.nih.gov/pubmed/34143816 http://dx.doi.org/10.1371/journal.pone.0253074 |
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