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High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa

As part of the human papillomavirus (HPV) vaccination strategy in South Africa, it is essential to have information on HPV prevalence, and HPV types distribution among the unvaccinated population. Information on the prevalence of HPV and the distribution of HPV types in adolescents and young women i...

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Autores principales: Mbulawa, Zizipho Z. A., Somdyala, Nontuthuzelo I., Mabunda, Sikhumbuzo A., Williamson, Anna-Lise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213156/
https://www.ncbi.nlm.nih.gov/pubmed/34143816
http://dx.doi.org/10.1371/journal.pone.0253074
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author Mbulawa, Zizipho Z. A.
Somdyala, Nontuthuzelo I.
Mabunda, Sikhumbuzo A.
Williamson, Anna-Lise
author_facet Mbulawa, Zizipho Z. A.
Somdyala, Nontuthuzelo I.
Mabunda, Sikhumbuzo A.
Williamson, Anna-Lise
author_sort Mbulawa, Zizipho Z. A.
collection PubMed
description As part of the human papillomavirus (HPV) vaccination strategy in South Africa, it is essential to have information on HPV prevalence, and HPV types distribution among the unvaccinated population. Information on the prevalence of HPV and the distribution of HPV types in adolescents and young women in South Africa’s Eastern Cape Province is minimal. Therefore, this study investigates the prevalence, distribution of HPV types, and factors associated with HPV infection amongst unvaccinated female learners. A sample composed of 213 sexually active female learners attending high schools in the Eastern Cape Province of South Africa; median age 18 years, who provided self-collected vaginal specimens. Roche Linear Array HPV genotyping assay that detects 37 HPV genotypes was used to detect HPV infection. HPV infection was detected in 76.06% (162/213) of participants. Of these 14.55% (31/213) were positive for HPV types targeted by the Cervarix® HPV vaccine (HPV-16 and/or 18), 20.66% (44/213) by Gardasil®4 (HPV-6, -11, -16 and/or -18) and 37.09% (79/213) by Gardasil®9 (HPV-6, -11, -16, -18, -31, -33, -45, -52 and/or -58). HPV-35, commonly detected in cervical cancer cases among women of African ancestry, was frequently detected (9.40%). Participants who reported to have ever consumed alcohol had a significantly higher risk of HPV infection (OR: 2.91, 95% CI: 1.38–6.11, p = 0.005). High HPV prevalence was observed among participants. The high prevalence of HPV types targeted by the Gardasil®9 vaccine encourages the introduction of the Gardasil®9 vaccine. Data from this study will inform both vaccination campaigns and monitor the impact on HPV types after vaccination.
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spelling pubmed-82131562021-06-29 High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa Mbulawa, Zizipho Z. A. Somdyala, Nontuthuzelo I. Mabunda, Sikhumbuzo A. Williamson, Anna-Lise PLoS One Research Article As part of the human papillomavirus (HPV) vaccination strategy in South Africa, it is essential to have information on HPV prevalence, and HPV types distribution among the unvaccinated population. Information on the prevalence of HPV and the distribution of HPV types in adolescents and young women in South Africa’s Eastern Cape Province is minimal. Therefore, this study investigates the prevalence, distribution of HPV types, and factors associated with HPV infection amongst unvaccinated female learners. A sample composed of 213 sexually active female learners attending high schools in the Eastern Cape Province of South Africa; median age 18 years, who provided self-collected vaginal specimens. Roche Linear Array HPV genotyping assay that detects 37 HPV genotypes was used to detect HPV infection. HPV infection was detected in 76.06% (162/213) of participants. Of these 14.55% (31/213) were positive for HPV types targeted by the Cervarix® HPV vaccine (HPV-16 and/or 18), 20.66% (44/213) by Gardasil®4 (HPV-6, -11, -16 and/or -18) and 37.09% (79/213) by Gardasil®9 (HPV-6, -11, -16, -18, -31, -33, -45, -52 and/or -58). HPV-35, commonly detected in cervical cancer cases among women of African ancestry, was frequently detected (9.40%). Participants who reported to have ever consumed alcohol had a significantly higher risk of HPV infection (OR: 2.91, 95% CI: 1.38–6.11, p = 0.005). High HPV prevalence was observed among participants. The high prevalence of HPV types targeted by the Gardasil®9 vaccine encourages the introduction of the Gardasil®9 vaccine. Data from this study will inform both vaccination campaigns and monitor the impact on HPV types after vaccination. Public Library of Science 2021-06-18 /pmc/articles/PMC8213156/ /pubmed/34143816 http://dx.doi.org/10.1371/journal.pone.0253074 Text en © 2021 Mbulawa et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mbulawa, Zizipho Z. A.
Somdyala, Nontuthuzelo I.
Mabunda, Sikhumbuzo A.
Williamson, Anna-Lise
High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa
title High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa
title_full High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa
title_fullStr High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa
title_full_unstemmed High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa
title_short High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa
title_sort high human papillomavirus prevalence among females attending high school in the eastern cape province of south africa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213156/
https://www.ncbi.nlm.nih.gov/pubmed/34143816
http://dx.doi.org/10.1371/journal.pone.0253074
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