ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication

53BP1 activates nonhomologous end joining (NHEJ) and inhibits homologous recombination (HR) repair of DNA double-strand breaks (DSBs). Dissociation of 53BP1 from DSBs and consequent activation of HR, a less error-prone pathway than NHEJ, helps maintain genome integrity during DNA replication; howeve...

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Detalles Bibliográficos
Autores principales: Wang, Dejie, Ma, Jian, Botuyan, Maria Victoria, Cui, Gaofeng, Yan, Yuqian, Ding, Donglin, Zhou, Yingke, Krueger, Eugene W., Pei, Jiang, Wu, Xiaosheng, Wang, Liguo, Pei, Huadong, McNiven, Mark A., Ye, Dingwei, Mer, Georges, Huang, Haojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213225/
https://www.ncbi.nlm.nih.gov/pubmed/34144977
http://dx.doi.org/10.1126/sciadv.abd9208

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