Two mechanisms of chromosome fragility at replication-termination sites in bacteria

Chromosomal fragile sites are implicated in promoting genome instability, which drives cancers and neurological diseases. Yet, the causes and mechanisms of chromosome fragility remain speculative. Here, we identify three spontaneous fragile sites in the Escherichia coli genome and define their DNA d...

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Detalles Bibliográficos
Autores principales: Mei, Qian, Fitzgerald, Devon M., Liu, Jingjing, Xia, Jun, Pribis, John P., Zhai, Yin, Nehring, Ralf B., Paiano, Jacob, Li, Heyuan, Nussenzweig, Andre, Hastings, P.J., Rosenberg, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213236/
https://www.ncbi.nlm.nih.gov/pubmed/34144978
http://dx.doi.org/10.1126/sciadv.abe2846

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