Bone Morphogenetic Protein Antagonist Gremlin-1 Increases Myofibroblast Transition in Dermal Fibroblasts: Implications for Systemic Sclerosis

OBJECTIVE: Systemic Sclerosis is an autoimmune connective tissue disease which results in fibrosis of the skin and lungs. The disease is characterized by activation of myofibroblasts but what governs this is unknown. Gremlin-1 is a BMP antagonist that is developmentally regulated and we sought to in...

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Detalles Bibliográficos
Autores principales: Duffy, Laura, Henderson, John, Brown, Max, Pryzborski, Stefan, Fullard, Nicola, Summa, Lena, Distler, Jorg H. W., Stratton, Richard, O’Reilly, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213337/
https://www.ncbi.nlm.nih.gov/pubmed/34150776
http://dx.doi.org/10.3389/fcell.2021.681061

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