N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications

N6-methyladenosine (m6A) is the most prevalent internal mRNA modification. m6A can be installed by the methyltransferase complex and removed by demethylases, which are involved in regulating post-transcriptional expression of target genes. RNA methylation is linked to various inflammatory states, in...

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Autores principales: Luo, Jiahui, Xu, Tao, Sun, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213350/
https://www.ncbi.nlm.nih.gov/pubmed/34150765
http://dx.doi.org/10.3389/fcell.2021.670711
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author Luo, Jiahui
Xu, Tao
Sun, Kai
author_facet Luo, Jiahui
Xu, Tao
Sun, Kai
author_sort Luo, Jiahui
collection PubMed
description N6-methyladenosine (m6A) is the most prevalent internal mRNA modification. m6A can be installed by the methyltransferase complex and removed by demethylases, which are involved in regulating post-transcriptional expression of target genes. RNA methylation is linked to various inflammatory states, including autoimmunity, infection, metabolic disease, cancer, neurodegenerative diseases, heart diseases, and bone diseases. However, systematic knowledge of the relationship between m6A modification and inflammation in human diseases remains unclear. In this review, we will discuss the association between m6A modification and inflammatory response in diseases, especially the role, mechanisms, and potential clinical application of m6A as a biomarker and therapeutic target for inflammatory diseases.
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spelling pubmed-82133502021-06-19 N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications Luo, Jiahui Xu, Tao Sun, Kai Front Cell Dev Biol Cell and Developmental Biology N6-methyladenosine (m6A) is the most prevalent internal mRNA modification. m6A can be installed by the methyltransferase complex and removed by demethylases, which are involved in regulating post-transcriptional expression of target genes. RNA methylation is linked to various inflammatory states, including autoimmunity, infection, metabolic disease, cancer, neurodegenerative diseases, heart diseases, and bone diseases. However, systematic knowledge of the relationship between m6A modification and inflammation in human diseases remains unclear. In this review, we will discuss the association between m6A modification and inflammatory response in diseases, especially the role, mechanisms, and potential clinical application of m6A as a biomarker and therapeutic target for inflammatory diseases. Frontiers Media S.A. 2021-06-04 /pmc/articles/PMC8213350/ /pubmed/34150765 http://dx.doi.org/10.3389/fcell.2021.670711 Text en Copyright © 2021 Luo, Xu and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Luo, Jiahui
Xu, Tao
Sun, Kai
N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications
title N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications
title_full N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications
title_fullStr N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications
title_full_unstemmed N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications
title_short N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications
title_sort n6-methyladenosine rna modification in inflammation: roles, mechanisms, and applications
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213350/
https://www.ncbi.nlm.nih.gov/pubmed/34150765
http://dx.doi.org/10.3389/fcell.2021.670711
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