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Recent progress on the mutations of SARS-CoV-2 spike protein and suggestions for prevention and controlling of the pandemic

Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection has caused a global pandemic in the past year, which poses continuing threat to human beings. To date, more than 3561 mutations in the viral spike protein were identified, including 2434 mutations that cause amino acid chang...

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Autores principales: Li, Xue, Zhang, Liying, Chen, Si, Ji, Weilong, Li, Chang, Ren, Linzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213438/
https://www.ncbi.nlm.nih.gov/pubmed/34146731
http://dx.doi.org/10.1016/j.meegid.2021.104971
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author Li, Xue
Zhang, Liying
Chen, Si
Ji, Weilong
Li, Chang
Ren, Linzhu
author_facet Li, Xue
Zhang, Liying
Chen, Si
Ji, Weilong
Li, Chang
Ren, Linzhu
author_sort Li, Xue
collection PubMed
description Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection has caused a global pandemic in the past year, which poses continuing threat to human beings. To date, more than 3561 mutations in the viral spike protein were identified, including 2434 mutations that cause amino acid changes with 343 amino acids located in the viral receptor-binding domain (RBD). Among these mutations, the most representative ones are substitution mutations such as D614G, N501Y, Y453F, N439K/R, P681H, K417N/T, and E484K, and deletion mutations of ΔH69/V70 and Δ242–244, which confer the virus with enhanced infectivity, transmissibility, and resistance to neutralization. In this review, we discussed the recent findings of SARS-CoV-2 for highlighting mutations and variants on virus transmissibility and pathogenicity. Moreover, several suggestions for prevention and controlling the pandemic are also proposed
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spelling pubmed-82134382021-06-21 Recent progress on the mutations of SARS-CoV-2 spike protein and suggestions for prevention and controlling of the pandemic Li, Xue Zhang, Liying Chen, Si Ji, Weilong Li, Chang Ren, Linzhu Infect Genet Evol Review Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection has caused a global pandemic in the past year, which poses continuing threat to human beings. To date, more than 3561 mutations in the viral spike protein were identified, including 2434 mutations that cause amino acid changes with 343 amino acids located in the viral receptor-binding domain (RBD). Among these mutations, the most representative ones are substitution mutations such as D614G, N501Y, Y453F, N439K/R, P681H, K417N/T, and E484K, and deletion mutations of ΔH69/V70 and Δ242–244, which confer the virus with enhanced infectivity, transmissibility, and resistance to neutralization. In this review, we discussed the recent findings of SARS-CoV-2 for highlighting mutations and variants on virus transmissibility and pathogenicity. Moreover, several suggestions for prevention and controlling the pandemic are also proposed Elsevier B.V. 2021-09 2021-06-17 /pmc/articles/PMC8213438/ /pubmed/34146731 http://dx.doi.org/10.1016/j.meegid.2021.104971 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Li, Xue
Zhang, Liying
Chen, Si
Ji, Weilong
Li, Chang
Ren, Linzhu
Recent progress on the mutations of SARS-CoV-2 spike protein and suggestions for prevention and controlling of the pandemic
title Recent progress on the mutations of SARS-CoV-2 spike protein and suggestions for prevention and controlling of the pandemic
title_full Recent progress on the mutations of SARS-CoV-2 spike protein and suggestions for prevention and controlling of the pandemic
title_fullStr Recent progress on the mutations of SARS-CoV-2 spike protein and suggestions for prevention and controlling of the pandemic
title_full_unstemmed Recent progress on the mutations of SARS-CoV-2 spike protein and suggestions for prevention and controlling of the pandemic
title_short Recent progress on the mutations of SARS-CoV-2 spike protein and suggestions for prevention and controlling of the pandemic
title_sort recent progress on the mutations of sars-cov-2 spike protein and suggestions for prevention and controlling of the pandemic
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213438/
https://www.ncbi.nlm.nih.gov/pubmed/34146731
http://dx.doi.org/10.1016/j.meegid.2021.104971
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