Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma

Thyroid-associated ophthalmopathy (TAO) is an inflammation of the extraocular muscles and periorbital connective tissue caused by autoantibodies against common antigens to both the thyroid and orbit. The release of antigens and induction of hypothyroidism caused by radioactive iodine (RAI) therapy m...

Descripción completa

Detalles Bibliográficos
Autores principales: Murayama, Daisuke, Toda, Soji, Okubo, Yoichiro, Hayashi, Hiroyuki, Matsui, Ai, Yasukawa, Mio, Iwasaki, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213507/
https://www.ncbi.nlm.nih.gov/pubmed/34221517
http://dx.doi.org/10.1155/2021/3024639
_version_ 1783709862804324352
author Murayama, Daisuke
Toda, Soji
Okubo, Yoichiro
Hayashi, Hiroyuki
Matsui, Ai
Yasukawa, Mio
Iwasaki, Hiroyuki
author_facet Murayama, Daisuke
Toda, Soji
Okubo, Yoichiro
Hayashi, Hiroyuki
Matsui, Ai
Yasukawa, Mio
Iwasaki, Hiroyuki
author_sort Murayama, Daisuke
collection PubMed
description Thyroid-associated ophthalmopathy (TAO) is an inflammation of the extraocular muscles and periorbital connective tissue caused by autoantibodies against common antigens to both the thyroid and orbit. The release of antigens and induction of hypothyroidism caused by radioactive iodine (RAI) therapy may exacerbate TAO. Here, we present the case of a 67-year-old-woman treated with RAI therapy for metastatic follicular thyroid carcinoma who presented with TAO during the course of sorafenib administration. Tg and TgAb levels were gradually decreased with sorafenib and lenvatinib treatment, and TAO was improved without any ophthalmologic treatment.
format Online
Article
Text
id pubmed-8213507
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-82135072021-07-01 Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma Murayama, Daisuke Toda, Soji Okubo, Yoichiro Hayashi, Hiroyuki Matsui, Ai Yasukawa, Mio Iwasaki, Hiroyuki Case Rep Endocrinol Case Report Thyroid-associated ophthalmopathy (TAO) is an inflammation of the extraocular muscles and periorbital connective tissue caused by autoantibodies against common antigens to both the thyroid and orbit. The release of antigens and induction of hypothyroidism caused by radioactive iodine (RAI) therapy may exacerbate TAO. Here, we present the case of a 67-year-old-woman treated with RAI therapy for metastatic follicular thyroid carcinoma who presented with TAO during the course of sorafenib administration. Tg and TgAb levels were gradually decreased with sorafenib and lenvatinib treatment, and TAO was improved without any ophthalmologic treatment. Hindawi 2021-06-11 /pmc/articles/PMC8213507/ /pubmed/34221517 http://dx.doi.org/10.1155/2021/3024639 Text en Copyright © 2021 Daisuke Murayama et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Murayama, Daisuke
Toda, Soji
Okubo, Yoichiro
Hayashi, Hiroyuki
Matsui, Ai
Yasukawa, Mio
Iwasaki, Hiroyuki
Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma
title Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma
title_full Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma
title_fullStr Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma
title_full_unstemmed Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma
title_short Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma
title_sort thyroid-associated ophthalmopathy after radioactive iodine therapy for metastatic follicular thyroid carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213507/
https://www.ncbi.nlm.nih.gov/pubmed/34221517
http://dx.doi.org/10.1155/2021/3024639
work_keys_str_mv AT murayamadaisuke thyroidassociatedophthalmopathyafterradioactiveiodinetherapyformetastaticfollicularthyroidcarcinoma
AT todasoji thyroidassociatedophthalmopathyafterradioactiveiodinetherapyformetastaticfollicularthyroidcarcinoma
AT okuboyoichiro thyroidassociatedophthalmopathyafterradioactiveiodinetherapyformetastaticfollicularthyroidcarcinoma
AT hayashihiroyuki thyroidassociatedophthalmopathyafterradioactiveiodinetherapyformetastaticfollicularthyroidcarcinoma
AT matsuiai thyroidassociatedophthalmopathyafterradioactiveiodinetherapyformetastaticfollicularthyroidcarcinoma
AT yasukawamio thyroidassociatedophthalmopathyafterradioactiveiodinetherapyformetastaticfollicularthyroidcarcinoma
AT iwasakihiroyuki thyroidassociatedophthalmopathyafterradioactiveiodinetherapyformetastaticfollicularthyroidcarcinoma

Ejemplares similares