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Hampering the early aggregation of PrP-E200K protein by charge-based inhibitors: a computational study
A multilayered computational workflow was designed to identify a druggable binding site on the surface of the E200K pathogenic mutant of the human prion protein, and to investigate the effect of the binding of small molecules in the inhibition of the early aggregation of this protein. At this purpos...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213589/ https://www.ncbi.nlm.nih.gov/pubmed/34110550 http://dx.doi.org/10.1007/s10822-021-00393-7 |