Cargando…

Physico-chemical characterization of bilirubin-10-sulfonate and comparison of its acid–base behavior with unconjugated bilirubin

Unconjugated bilirubin (UCB) is the end-product of heme catabolism in the intravascular compartment. Although beneficial for human health when mildly elevated in the body, when present at greater than a critical threshold concentration, UCB exerts toxic effects that are related to its physico-chemic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Čepa, Adam, Dejmková, Veronika, Lešetický, Ladislav, Jelínek, Ivan, Smrček, Stanislav, Štícha, Martin, Jašprová, Jana, Urbanová, Marie, Goncharova, Iryna, Dračínský, Martin, Procházková, Eliška, Ostrow, Donald J., Vítek, Libor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213708/ https://www.ncbi.nlm.nih.gov/pubmed/34145377 http://dx.doi.org/10.1038/s41598-021-92377-8

Ejemplares similares

The Biological Effects of Bilirubin Photoisomers
por: Jasprova, Jana, et al.
Publicado: (2016)

Revalidation and rationale for high pKa values of unconjugated bilirubin
por: Ostrow, J Donald, et al.
Publicado: (2007)

Low solubility of unconjugated bilirubin in dimethylsulfoxide – water systems: implications for pK(a) determinations
por: Mukerjee, Pasupati, et al.
Publicado: (2002)

Unconjugated Bilirubin Attenuates DSS-Induced Colitis Potentially via Enhancement of Bilirubin Reabsorption
por: Zhao, Chong, et al.
Publicado: (2021)

Interactions of unconjugated bilirubin with vesicles, cyclodextrins and micelles: New modeling and the role of high pKa values
por: Mukerjee, Pasupati, et al.
Publicado: (2010)

Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes
por: Feng, Jie, et al.
Publicado: (2018)

Fluorescent protein-based detection of unconjugated bilirubin in newborn serum
por: Iwatani, Sota, et al.
Publicado: (2016)

Isolated Silymarin Flavonoids Increase Systemic and Hepatic Bilirubin Concentrations and Lower Lipoperoxidation in Mice
por: Šuk, Jakub, et al.
Publicado: (2019)

The Evolving Landscape of Neurotoxicity by Unconjugated Bilirubin: Role of Glial Cells and Inflammation
por: Brites, Dora
Publicado: (2012)

Unconjugated Bilirubin Exposure Impairs Hippocampal Long-Term Synaptic Plasticity
por: Chang, Fang-Yu, et al.
Publicado: (2009)

Neurotoxicity of Unconjugated Bilirubin in Neonatal Hypoxic-Ischemic Brain Injury in vitro
por: Dani, Carlo, et al.
Publicado: (2021)

The Role of Bilirubin in Diabetes, Metabolic Syndrome, and Cardiovascular Diseases
por: Vítek, Libor
Publicado: (2012)

Neuro-inflammatory effects of photodegradative products of bilirubin
por: Jašprová, J., et al.
Publicado: (2018)

Impact of voxelotor (GBT440) on unconjugated bilirubin and jaundice in sickle cell disease
por: Telfer, Paul, et al.
Publicado: (2018)

Unconjugated bilirubin ameliorates the inflammation and digestive protease increase in TNBS-induced colitis
por: Zhou, Jin-An, et al.
Publicado: (2017)

Exposure to Lipopolysaccharide and/or Unconjugated Bilirubin Impair the Integrity and Function of Brain Microvascular Endothelial Cells
por: Cardoso, Filipa L., et al.
Publicado: (2012)

The Role of Bilirubin and the Other “Yellow Players” in Neurodegenerative Diseases
por: Jayanti, Sri, et al.
Publicado: (2020)

Evaluation of Treatment Thresholds for Unconjugated Hyperbilirubinemia in Preterm Infants: Effects on Serum Bilirubin and on Hearing Loss?
por: Hulzebos, Christian V., et al.
Publicado: (2013)

Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation
por: NaveenKumar, Somanathapura K., et al.
Publicado: (2015)

Unconjugated bilirubin alleviates experimental ulcerative colitis by regulating intestinal barrier function and immune inflammation
por: Zheng, Jia-Dong, et al.
Publicado: (2019)

Hyperbilirubinemia Maintained by Chronic Supplementation of Unconjugated Bilirubin Improves the Clinical Course of Experimental Autoimmune Arthritis
por: Sykora, Tomas, et al.
Publicado: (2021)

Serum Bilirubin Concentrations and the Prevalence of Gilbert Syndrome in Elite Athletes
por: Woronyczová, Jana, et al.
Publicado: (2022)

Unprecedented Microbial Conversion of Biliverdin into Bilirubin-10-sulfonate
por: Shiels, Ryan G., et al.
Publicado: (2019)

Association of Serum Bilirubin and Functional Variants of Heme Oxygenase 1 and Bilirubin UDP-Glucuronosyl Transferase Genes in Czech Adult Patients with Non-Alcoholic Fatty Liver Disease
por: Petrtýl, Jaromír, et al.
Publicado: (2021)

Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining
por: Palmela, Inês, et al.
Publicado: (2012)

Relation between unconjugated bilirubin and RDW, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio in Gilbert’s syndrome
por: Sarlak, Hakan, et al.
Publicado: (2016)

Cutting edge concepts: Does bilirubin enhance exercise performance?
por: Flack, Kyle D., et al.
Publicado: (2023)

Expression profiling of N6-methyladenosine-modified mRNA in PC12 cells in response to unconjugated bilirubin
por: Zhou, Jinfu, et al.
Publicado: (2023)

The Effects of Bilirubin and Lumirubin on Metabolic and Oxidative Stress Markers
por: Dvořák, Aleš, et al.
Publicado: (2021)

A transcriptome analysis identifies molecular effectors of unconjugated bilirubin in human neuroblastoma SH-SY5Y cells
por: Calligaris, Raffaella, et al.
Publicado: (2009)

Low-normal serum unconjugated bilirubin levels are associated with late but not early carotid atherosclerotic lesions in T2DM subjects
por: Jin, Chun-Hua, et al.
Publicado: (2022)

Measuring endogenous levels of unconjugated bilirubin released from isolated murine brain tissue during oxygen-glucose deprivation
por: Liu, Han-Wei, et al.
Publicado: (2023)

Functional Induction of the Cystine-Glutamate Exchanger System X(c) (-) Activity in SH-SY5Y Cells by Unconjugated Bilirubin
por: Giraudi, Pablo J., et al.
Publicado: (2011)

Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study
por: Palmela, Inês, et al.
Publicado: (2015)

A Perspective on a Possible Relation Between the Psychopathology of the Schizophrenia/Schizoaffective Spectrum and Unconjugated Bilirubin: A Longitudinal Protocol Study
por: Gama Marques, João, et al.
Publicado: (2018)

Relation Between Unconjugated Bilirubin and Peripheral Biomarkers of Inflammation Derived From Complete Blood Counts in Patients With Acute Stage of Schizophrenia
por: Xu, Haiting, et al.
Publicado: (2022)

UGT1A1 mutation association with increased bilirubin levels and severity of unconjugated hyperbilirubinemia in ABO incompatible newborns of China
por: Yang, Hui, et al.
Publicado: (2021)

The Extent of Intracellular Accumulation of Bilirubin Determines Its Anti- or Pro-Oxidant Effect
por: Bianco, Annalisa, et al.
Publicado: (2020)

Serum Bilirubin and Markers of Oxidative Stress and Inflammation in a Healthy Population and in Patients with Various Forms of Atherosclerosis
por: Vítek, Libor, et al.
Publicado: (2022)

Inhibition of Lipid Accumulation in Skeletal Muscle and Liver Cells: A Protective Mechanism of Bilirubin Against Diabetes Mellitus Type 2
por: Hana, Claudia A., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_b5dbj5fbl6aqtfuttcpupld2so