Cargando…
Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors
Autism spectrum disorder (ASD) is a neurodevelopmental disease associated with various gene mutations. Recent genetic and clinical studies report that mutations of the epigenetic gene ASH1L are highly associated with human ASD and intellectual disability (ID). However, the causality and underlying m...
Autores principales: | Gao, Yuen, Duque-Wilckens, Natalia, Aljazi, Mohammad B., Wu, Yan, Moeser, Adam J., Mias, George I., Robison, Alfred J., He, Jin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213741/ https://www.ncbi.nlm.nih.gov/pubmed/34145365 http://dx.doi.org/10.1038/s42003-021-02282-z |
Ejemplares similares
-
Impaired KDM2B-mediated PRC1 recruitment to chromatin causes defective neural stem cell self-renewal and ASD/ID-like behaviors
por: Gao, Yuen, et al.
Publicado: (2022) -
Histone H3K36me2-Specific Methyltransferase ASH1L Promotes MLL-AF9-Induced Leukemogenesis
por: Aljazi, Mohammad B., et al.
Publicado: (2021) -
The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice
por: Li, Gang, et al.
Publicado: (2017) -
Neural Hyperactivity Is a Core Pathophysiological Change Induced by Deletion of a High Autism Risk Gene Ash1L in the Mouse Brain
por: Gao, Yuen, et al.
Publicado: (2022) -
Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone
methyltransferase Trr
por: Carbonell, Albert, et al.
Publicado: (2013)