Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station

Sixteen-week-old female C57BL/6J mice were sacrificed aboard the International Space Station after 37 days of flight (RR-1 mission) and frozen carcasses returned to Earth. RNA was isolated from interscapular brown adipose tissue (BAT) and gonadal white adipose tissue (WAT). Spaceflight resulted in d...

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Detalles Bibliográficos
Autores principales: Wong, Carmen P., Iwaniec, Urszula T., Turner, Russell T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213760/
https://www.ncbi.nlm.nih.gov/pubmed/34145277
http://dx.doi.org/10.1038/s41526-021-00150-y
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author Wong, Carmen P.
Iwaniec, Urszula T.
Turner, Russell T.
author_facet Wong, Carmen P.
Iwaniec, Urszula T.
Turner, Russell T.
author_sort Wong, Carmen P.
collection PubMed
description Sixteen-week-old female C57BL/6J mice were sacrificed aboard the International Space Station after 37 days of flight (RR-1 mission) and frozen carcasses returned to Earth. RNA was isolated from interscapular brown adipose tissue (BAT) and gonadal white adipose tissue (WAT). Spaceflight resulted in differential expression of genes in BAT consistent with increased non-shivering thermogenesis and differential expression of genes in WAT consistent with increased glucose uptake and metabolism, adipogenesis, and β-oxidation.
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spelling pubmed-82137602021-07-01 Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station Wong, Carmen P. Iwaniec, Urszula T. Turner, Russell T. NPJ Microgravity Brief Communication Sixteen-week-old female C57BL/6J mice were sacrificed aboard the International Space Station after 37 days of flight (RR-1 mission) and frozen carcasses returned to Earth. RNA was isolated from interscapular brown adipose tissue (BAT) and gonadal white adipose tissue (WAT). Spaceflight resulted in differential expression of genes in BAT consistent with increased non-shivering thermogenesis and differential expression of genes in WAT consistent with increased glucose uptake and metabolism, adipogenesis, and β-oxidation. Nature Publishing Group UK 2021-06-18 /pmc/articles/PMC8213760/ /pubmed/34145277 http://dx.doi.org/10.1038/s41526-021-00150-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Wong, Carmen P.
Iwaniec, Urszula T.
Turner, Russell T.
Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title_full Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title_fullStr Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title_full_unstemmed Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title_short Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
title_sort evidence for increased thermogenesis in female c57bl/6j mice housed aboard the international space station
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213760/
https://www.ncbi.nlm.nih.gov/pubmed/34145277
http://dx.doi.org/10.1038/s41526-021-00150-y
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