Cargando…

Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures

Community mitigation strategies to combat COVID-19, ranging from healthy hygiene to shelter-in-place orders, exact substantial socioeconomic costs. Judicious implementation and relaxation of restrictions amplify their public health benefits while reducing costs. We derive optimal strategies for togg...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Haoxiang, Sürer, Özge, Duque, Daniel, Morton, David P., Singh, Bismark, Fox, Spencer J., Pasco, Remy, Pierce, Kelly, Rathouz, Paul, Valencia, Victoria, Du, Zhanwei, Pignone, Michael, Escott, Mark E., Adler, Stephen I., Johnston, S. Claiborne, Meyers, Lauren Ancel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213780/
https://www.ncbi.nlm.nih.gov/pubmed/34145252
http://dx.doi.org/10.1038/s41467-021-23989-x
_version_ 1783709926156140544
author Yang, Haoxiang
Sürer, Özge
Duque, Daniel
Morton, David P.
Singh, Bismark
Fox, Spencer J.
Pasco, Remy
Pierce, Kelly
Rathouz, Paul
Valencia, Victoria
Du, Zhanwei
Pignone, Michael
Escott, Mark E.
Adler, Stephen I.
Johnston, S. Claiborne
Meyers, Lauren Ancel
author_facet Yang, Haoxiang
Sürer, Özge
Duque, Daniel
Morton, David P.
Singh, Bismark
Fox, Spencer J.
Pasco, Remy
Pierce, Kelly
Rathouz, Paul
Valencia, Victoria
Du, Zhanwei
Pignone, Michael
Escott, Mark E.
Adler, Stephen I.
Johnston, S. Claiborne
Meyers, Lauren Ancel
author_sort Yang, Haoxiang
collection PubMed
description Community mitigation strategies to combat COVID-19, ranging from healthy hygiene to shelter-in-place orders, exact substantial socioeconomic costs. Judicious implementation and relaxation of restrictions amplify their public health benefits while reducing costs. We derive optimal strategies for toggling between mitigation stages using daily COVID-19 hospital admissions. With public compliance, the policy triggers ensure adequate intensive care unit capacity with high probability while minimizing the duration of strict mitigation measures. In comparison, we show that other sensible COVID-19 staging policies, including France’s ICU-based thresholds and a widely adopted indicator for reopening schools and businesses, require overly restrictive measures or trigger strict stages too late to avert catastrophic surges. As proof-of-concept, we describe the optimization and maintenance of the staged alert system that has guided COVID-19 policy in a large US city (Austin, Texas) since May 2020. As cities worldwide face future pandemic waves, our findings provide a robust strategy for tracking COVID-19 hospital admissions as an early indicator of hospital surges and enacting staged measures to ensure integrity of the health system, safety of the health workforce, and public confidence.
format Online
Article
Text
id pubmed-8213780
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-82137802021-07-01 Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures Yang, Haoxiang Sürer, Özge Duque, Daniel Morton, David P. Singh, Bismark Fox, Spencer J. Pasco, Remy Pierce, Kelly Rathouz, Paul Valencia, Victoria Du, Zhanwei Pignone, Michael Escott, Mark E. Adler, Stephen I. Johnston, S. Claiborne Meyers, Lauren Ancel Nat Commun Article Community mitigation strategies to combat COVID-19, ranging from healthy hygiene to shelter-in-place orders, exact substantial socioeconomic costs. Judicious implementation and relaxation of restrictions amplify their public health benefits while reducing costs. We derive optimal strategies for toggling between mitigation stages using daily COVID-19 hospital admissions. With public compliance, the policy triggers ensure adequate intensive care unit capacity with high probability while minimizing the duration of strict mitigation measures. In comparison, we show that other sensible COVID-19 staging policies, including France’s ICU-based thresholds and a widely adopted indicator for reopening schools and businesses, require overly restrictive measures or trigger strict stages too late to avert catastrophic surges. As proof-of-concept, we describe the optimization and maintenance of the staged alert system that has guided COVID-19 policy in a large US city (Austin, Texas) since May 2020. As cities worldwide face future pandemic waves, our findings provide a robust strategy for tracking COVID-19 hospital admissions as an early indicator of hospital surges and enacting staged measures to ensure integrity of the health system, safety of the health workforce, and public confidence. Nature Publishing Group UK 2021-06-18 /pmc/articles/PMC8213780/ /pubmed/34145252 http://dx.doi.org/10.1038/s41467-021-23989-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yang, Haoxiang
Sürer, Özge
Duque, Daniel
Morton, David P.
Singh, Bismark
Fox, Spencer J.
Pasco, Remy
Pierce, Kelly
Rathouz, Paul
Valencia, Victoria
Du, Zhanwei
Pignone, Michael
Escott, Mark E.
Adler, Stephen I.
Johnston, S. Claiborne
Meyers, Lauren Ancel
Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures
title Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures
title_full Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures
title_fullStr Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures
title_full_unstemmed Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures
title_short Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures
title_sort design of covid-19 staged alert systems to ensure healthcare capacity with minimal closures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213780/
https://www.ncbi.nlm.nih.gov/pubmed/34145252
http://dx.doi.org/10.1038/s41467-021-23989-x
work_keys_str_mv AT yanghaoxiang designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures
AT surerozge designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures
AT duquedaniel designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures
AT mortondavidp designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures
AT singhbismark designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures
AT foxspencerj designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures
AT pascoremy designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures
AT piercekelly designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures
AT rathouzpaul designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures
AT valenciavictoria designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures
AT duzhanwei designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures
AT pignonemichael designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures
AT escottmarke designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures
AT adlerstepheni designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures
AT johnstonsclaiborne designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures
AT meyerslaurenancel designofcovid19stagedalertsystemstoensurehealthcarecapacitywithminimalclosures