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Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures
Community mitigation strategies to combat COVID-19, ranging from healthy hygiene to shelter-in-place orders, exact substantial socioeconomic costs. Judicious implementation and relaxation of restrictions amplify their public health benefits while reducing costs. We derive optimal strategies for togg...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213780/ https://www.ncbi.nlm.nih.gov/pubmed/34145252 http://dx.doi.org/10.1038/s41467-021-23989-x |
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author | Yang, Haoxiang Sürer, Özge Duque, Daniel Morton, David P. Singh, Bismark Fox, Spencer J. Pasco, Remy Pierce, Kelly Rathouz, Paul Valencia, Victoria Du, Zhanwei Pignone, Michael Escott, Mark E. Adler, Stephen I. Johnston, S. Claiborne Meyers, Lauren Ancel |
author_facet | Yang, Haoxiang Sürer, Özge Duque, Daniel Morton, David P. Singh, Bismark Fox, Spencer J. Pasco, Remy Pierce, Kelly Rathouz, Paul Valencia, Victoria Du, Zhanwei Pignone, Michael Escott, Mark E. Adler, Stephen I. Johnston, S. Claiborne Meyers, Lauren Ancel |
author_sort | Yang, Haoxiang |
collection | PubMed |
description | Community mitigation strategies to combat COVID-19, ranging from healthy hygiene to shelter-in-place orders, exact substantial socioeconomic costs. Judicious implementation and relaxation of restrictions amplify their public health benefits while reducing costs. We derive optimal strategies for toggling between mitigation stages using daily COVID-19 hospital admissions. With public compliance, the policy triggers ensure adequate intensive care unit capacity with high probability while minimizing the duration of strict mitigation measures. In comparison, we show that other sensible COVID-19 staging policies, including France’s ICU-based thresholds and a widely adopted indicator for reopening schools and businesses, require overly restrictive measures or trigger strict stages too late to avert catastrophic surges. As proof-of-concept, we describe the optimization and maintenance of the staged alert system that has guided COVID-19 policy in a large US city (Austin, Texas) since May 2020. As cities worldwide face future pandemic waves, our findings provide a robust strategy for tracking COVID-19 hospital admissions as an early indicator of hospital surges and enacting staged measures to ensure integrity of the health system, safety of the health workforce, and public confidence. |
format | Online Article Text |
id | pubmed-8213780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82137802021-07-01 Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures Yang, Haoxiang Sürer, Özge Duque, Daniel Morton, David P. Singh, Bismark Fox, Spencer J. Pasco, Remy Pierce, Kelly Rathouz, Paul Valencia, Victoria Du, Zhanwei Pignone, Michael Escott, Mark E. Adler, Stephen I. Johnston, S. Claiborne Meyers, Lauren Ancel Nat Commun Article Community mitigation strategies to combat COVID-19, ranging from healthy hygiene to shelter-in-place orders, exact substantial socioeconomic costs. Judicious implementation and relaxation of restrictions amplify their public health benefits while reducing costs. We derive optimal strategies for toggling between mitigation stages using daily COVID-19 hospital admissions. With public compliance, the policy triggers ensure adequate intensive care unit capacity with high probability while minimizing the duration of strict mitigation measures. In comparison, we show that other sensible COVID-19 staging policies, including France’s ICU-based thresholds and a widely adopted indicator for reopening schools and businesses, require overly restrictive measures or trigger strict stages too late to avert catastrophic surges. As proof-of-concept, we describe the optimization and maintenance of the staged alert system that has guided COVID-19 policy in a large US city (Austin, Texas) since May 2020. As cities worldwide face future pandemic waves, our findings provide a robust strategy for tracking COVID-19 hospital admissions as an early indicator of hospital surges and enacting staged measures to ensure integrity of the health system, safety of the health workforce, and public confidence. Nature Publishing Group UK 2021-06-18 /pmc/articles/PMC8213780/ /pubmed/34145252 http://dx.doi.org/10.1038/s41467-021-23989-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Yang, Haoxiang Sürer, Özge Duque, Daniel Morton, David P. Singh, Bismark Fox, Spencer J. Pasco, Remy Pierce, Kelly Rathouz, Paul Valencia, Victoria Du, Zhanwei Pignone, Michael Escott, Mark E. Adler, Stephen I. Johnston, S. Claiborne Meyers, Lauren Ancel Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures |
title | Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures |
title_full | Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures |
title_fullStr | Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures |
title_full_unstemmed | Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures |
title_short | Design of COVID-19 staged alert systems to ensure healthcare capacity with minimal closures |
title_sort | design of covid-19 staged alert systems to ensure healthcare capacity with minimal closures |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213780/ https://www.ncbi.nlm.nih.gov/pubmed/34145252 http://dx.doi.org/10.1038/s41467-021-23989-x |
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