Uridine and pyruvate protect T cells’ proliferative capacity from mitochondrial toxic antibiotics: a clinical pilot study

Antibiotics that inhibit bacterial protein or nucleic acid synthesis and function can exert an off-target action on mitochondria (mitotoxic antibiotics), making actively dividing mammalian cells dependent on uridine and pyruvate supplementation. Based on this rationale, we carried out, for the first...

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Detalles Bibliográficos
Autores principales: Battaglia, Stefano, De Santis, Stefania, Rutigliano, Monica, Sallustio, Fabio, Picerno, Angela, Frassanito, Maria Antonia, Schaefer, Ingo, Vacca, Angelo, Moschetta, Antonio, Seibel, Peter, Battaglia, Michele, Villani, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213784/
https://www.ncbi.nlm.nih.gov/pubmed/34145306
http://dx.doi.org/10.1038/s41598-021-91559-8

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