Cargando…

Mechanism of genome instability mediated by human DNA polymerase mu misincorporation

Pol μ is capable of performing gap-filling repair synthesis in the nonhomologous end joining (NHEJ) pathway. Together with DNA ligase, misincorporation of dGTP opposite the templating T by Pol μ results in a promutagenic T:G mispair, leading to genomic instability. Here, crystal structures and kinet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Miao, Wang, Yina, Tang, Yuyue, Chen, Zijing, Hou, Jinfeng, Dai, Jingli, Wang, Yudong, Wang, Liangyan, Xu, Hong, Tian, Bing, Hua, Yuejin, Zhao, Ye
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213813/ https://www.ncbi.nlm.nih.gov/pubmed/34145298 http://dx.doi.org/10.1038/s41467-021-24096-7

Ejemplares similares

MazEF Toxin-Antitoxin System-Mediated DNA Damage Stress Response in Deinococcus radiodurans
por: Dai, Jingli, et al.
Publicado: (2021)

Phosphorylation Regulation of a Histone-like HU Protein from Deinococcus radiodurans
por: Hou, Jinfeng, et al.
Publicado: (2022)

In crystallo observation of three metal ion promoted DNA polymerase misincorporation
por: Chang, Caleb, et al.
Publicado: (2022)

Misincorporation by RNA polymerase is a major source of transcription pausing in vivo
por: James, Katherine, et al.
Publicado: (2017)

MoaE Is Involved in Response to Oxidative Stress in Deinococcus radiodurans
por: Cai, Jianling, et al.
Publicado: (2023)

Unique 5′-P recognition and basis for dG:dGTP misincorporation of ASFV DNA polymerase X
por: Chen, Yiqing, et al.
Publicado: (2017)

Incorporation of inosine into DNA by human polymerase eta (Polη): kinetics of nucleotide misincorporation and structural basis for the mutagenicity
por: Zhang, Qi, et al.
Publicado: (2023)

Structural basis for DNA 5´-end resection by RecJ
por: Cheng, Kaiying, et al.
Publicado: (2016)

Structural features and functional implications of proteins enabling the robustness of Deinococcus radiodurans
por: Chen, Zijing, et al.
Publicado: (2020)

Characterization of Nucleotide Misincorporation Patterns in the Iceman's Mitochondrial DNA
por: Olivieri, Cristina, et al.
Publicado: (2010)

Misincorporation Proteomics Technologies: A Review
por: Steele, Joel R., et al.
Publicado: (2021)

Temporal Patterns of Nucleotide Misincorporations and DNA Fragmentation in Ancient DNA
por: Sawyer, Susanna, et al.
Publicado: (2012)

Comparative Study of Cyanobacterial and E. coli RNA Polymerases: Misincorporation, Abortive Transcription, and Dependence on Divalent Cations
por: Imashimizu, Masahiko, et al.
Publicado: (2011)

Conformational dynamics during misincorporation and mismatch extension defined using a DNA polymerase with a fluorescent artificial amino acid
por: Dangerfield, Tyler L., et al.
Publicado: (2021)

Characteristics of dr1790 disruptant and its functional analysis in Deinococcus radiodurans
por: Cheng, Jianhui, et al.
Publicado: (2015)

DRJAMM Is Involved in the Oxidative Resistance in Deinococcus radiodurans
por: Cai, Jianling, et al.
Publicado: (2022)

Errors in translational decoding: tRNA wobbling or misincorporation?
por: Ou, Xumin, et al.
Publicado: (2019)

Disease-associated inosine misincorporation into RNA hinders translation
por: Schroader, Jacob H, et al.
Publicado: (2022)

N(4)-Cytosine DNA Methylation Is Involved in the Maintenance of Genomic Stability in Deinococcus radiodurans
por: Li, Shengjie, et al.
Publicado: (2019)

Dielectricity of a molecularly crowded solution accelerates NTP misincorporation during RNA-dependent RNA polymerization by T7 RNA polymerase
por: Takahashi, Shuntaro, et al.
Publicado: (2022)

How the misincorporation of ribonucleotides into genomic DNA can be both harmful and helpful to cells
por: Potenski, Catherine J., et al.
Publicado: (2014)

Ribonucleotides Misincorporated into DNA Act as Strand-Discrimination Signals in Eukaryotic Mismatch Repair
por: Ghodgaonkar, Medini Manohar, et al.
Publicado: (2013)

A Novel C-Terminal Domain of RecJ is Critical for Interaction with HerA in Deinococcus radiodurans
por: Cheng, Kaiying, et al.
Publicado: (2015)

Structural and Functional Characterization of the Holliday Junction Resolvase RuvC from Deinococcus radiodurans
por: Qin, Chen, et al.
Publicado: (2022)

Structure and DNA damage-dependent derepression mechanism for the XRE family member DG-DdrO
por: Lu, Huizhi, et al.
Publicado: (2019)

XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2′-Deoxycytidine and 5-Hydroxymethyl-2′-Deoxyuridine
por: Peña-Gómez, María José, et al.
Publicado: (2022)

Increased uracil misincorporation in lymphocytes from folate-deficient rats
por: Duthie, S J, et al.
Publicado: (2000)

MTHFR Knockdown Assists Cell Defense against Folate Depletion Induced Chromosome Segregation and Uracil Misincorporation in DNA
por: Wu, Ming-Tsung, et al.
Publicado: (2021)

Rare and misincorporated DNA N(6)-methyladenine is a hallmark of cytotoxic stresses for selectively stimulating the stemness and proliferation of glioblastoma cells
por: Lyu, Cong, et al.
Publicado: (2022)

Dynamic Basis for dG•dT misincorporation via tautomerization and ionization
por: Kimsey, Isaac J., et al.
Publicado: (2018)

Conditional accumulation of toxic tRNAs to cause amino acid misincorporation
por: Zimmerman, Stephanie M, et al.
Publicado: (2018)

Exposure to selenomethionine causes selenocysteine misincorporation and protein aggregation in Saccharomyces cerevisiae
por: Plateau, Pierre, et al.
Publicado: (2017)

Quantum Tunnelling Effects in the Guanine-Thymine Wobble Misincorporation via Tautomerism
por: Slocombe, Louie, et al.
Publicado: (2022)

Cyclic AMP Receptor Protein Acts as a Transcription Regulator in Response to Stresses in Deinococcus radiodurans
por: Yang, Su, et al.
Publicado: (2016)

Structural and Functional Characterization of a Unique AP Endonuclease From Deinococcus radiodurans
por: He, Yuan, et al.
Publicado: (2020)

Regulation of MntH by a Dual Mn(II)- and Fe(II)-Dependent Transcriptional Repressor (DR2539) in Deinococcus radiodurans
por: Sun, Hongxing, et al.
Publicado: (2012)

A Mur Regulator Protein in the Extremophilic Bacterium Deinococcus radiodurans
por: Ul Hussain Shah, Amir Miraj, et al.
Publicado: (2014)

Removal of Misincorporated Ribonucleotides from Prokaryotic Genomes: An Unexpected Role for Nucleotide Excision Repair
por: Vaisman, Alexandra, et al.
Publicado: (2013)

SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation
por: Paone, A, et al.
Publicado: (2014)

Identification of Lysine Misincorporation at Asparagine Position in Recombinant Insulin Analogs Produced in E. coli
por: Stadnik, Dorota, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_djln1lmj8ib5bqm43emvaq48mt