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Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice
The reward system, which consists of dopaminergic neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens and caudate-putamen in the striatum, has an important role in the pathogenesis of not only drug addiction but also diet-induced obesity. In the present study, we examin...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213822/ https://www.ncbi.nlm.nih.gov/pubmed/34145364 http://dx.doi.org/10.1038/s41598-021-92386-7 |
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author | Mizoguchi, Akira Banno, Ryoichi Sun, Runan Yaginuma, Hiroshi Taki, Keigo Kobayashi, Tomoko Sugiyama, Mariko Tsunekawa, Taku Onoue, Takeshi Takagi, Hiroshi Hagiwara, Daisuke Ito, Yoshihiro Iwama, Shintaro Suga, Hidetaka Nagai, Taku Yamada, Kiyofumi Arima, Hiroshi |
author_facet | Mizoguchi, Akira Banno, Ryoichi Sun, Runan Yaginuma, Hiroshi Taki, Keigo Kobayashi, Tomoko Sugiyama, Mariko Tsunekawa, Taku Onoue, Takeshi Takagi, Hiroshi Hagiwara, Daisuke Ito, Yoshihiro Iwama, Shintaro Suga, Hidetaka Nagai, Taku Yamada, Kiyofumi Arima, Hiroshi |
author_sort | Mizoguchi, Akira |
collection | PubMed |
description | The reward system, which consists of dopaminergic neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens and caudate-putamen in the striatum, has an important role in the pathogenesis of not only drug addiction but also diet-induced obesity. In the present study, we examined whether signaling through glucocorticoid receptors (GRs) in the reward system affects the rewarding value of a high-fat diet (HFD). To do so, we generated mice that lack functional GRs specifically in dopaminergic neurons (D-KO mice) or corticostriatal neurons (CS-KO mice), subjected the mice to caloric restriction stress conditions, and evaluated the rewarding value of a HFD by conditioned place preference (CPP) test. Caloric restriction induced increases in serum corticosterone to similar levels in all genotypes. While CS-KO as well as WT mice exhibited a significant preference for HFD in the CPP test, D-KO mice exhibited no such preference. There were no differences between WT and D-KO mice in consumption of HFD after fasting or cognitive function evaluated by a novel object recognition test. These data suggest that glucocorticoid signaling in the VTA increases the rewarding value of a HFD under restricted caloric stress. |
format | Online Article Text |
id | pubmed-8213822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82138222021-06-22 Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice Mizoguchi, Akira Banno, Ryoichi Sun, Runan Yaginuma, Hiroshi Taki, Keigo Kobayashi, Tomoko Sugiyama, Mariko Tsunekawa, Taku Onoue, Takeshi Takagi, Hiroshi Hagiwara, Daisuke Ito, Yoshihiro Iwama, Shintaro Suga, Hidetaka Nagai, Taku Yamada, Kiyofumi Arima, Hiroshi Sci Rep Article The reward system, which consists of dopaminergic neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens and caudate-putamen in the striatum, has an important role in the pathogenesis of not only drug addiction but also diet-induced obesity. In the present study, we examined whether signaling through glucocorticoid receptors (GRs) in the reward system affects the rewarding value of a high-fat diet (HFD). To do so, we generated mice that lack functional GRs specifically in dopaminergic neurons (D-KO mice) or corticostriatal neurons (CS-KO mice), subjected the mice to caloric restriction stress conditions, and evaluated the rewarding value of a HFD by conditioned place preference (CPP) test. Caloric restriction induced increases in serum corticosterone to similar levels in all genotypes. While CS-KO as well as WT mice exhibited a significant preference for HFD in the CPP test, D-KO mice exhibited no such preference. There were no differences between WT and D-KO mice in consumption of HFD after fasting or cognitive function evaluated by a novel object recognition test. These data suggest that glucocorticoid signaling in the VTA increases the rewarding value of a HFD under restricted caloric stress. Nature Publishing Group UK 2021-06-18 /pmc/articles/PMC8213822/ /pubmed/34145364 http://dx.doi.org/10.1038/s41598-021-92386-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Mizoguchi, Akira Banno, Ryoichi Sun, Runan Yaginuma, Hiroshi Taki, Keigo Kobayashi, Tomoko Sugiyama, Mariko Tsunekawa, Taku Onoue, Takeshi Takagi, Hiroshi Hagiwara, Daisuke Ito, Yoshihiro Iwama, Shintaro Suga, Hidetaka Nagai, Taku Yamada, Kiyofumi Arima, Hiroshi Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice |
title | Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice |
title_full | Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice |
title_fullStr | Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice |
title_full_unstemmed | Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice |
title_short | Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice |
title_sort | glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213822/ https://www.ncbi.nlm.nih.gov/pubmed/34145364 http://dx.doi.org/10.1038/s41598-021-92386-7 |
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