Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder

Bipolar disorder is a severe mental illness characterized by recurrent manic and depressive episodes. To better understand its genetic architecture, we analyze ultra-rare de novo mutations in 354 trios with bipolar disorder. For germline de novo mutations, we find significant enrichment of loss-of-f...

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Detalles Bibliográficos
Autores principales: Nishioka, Masaki, Kazuno, An-a, Nakamura, Takumi, Sakai, Naomi, Hayama, Takashi, Fujii, Kumiko, Matsuo, Koji, Komori, Atsuko, Ishiwata, Mizuho, Watanabe, Yoshinori, Oka, Takashi, Matoba, Nana, Kataoka, Muneko, Alkanaq, Ahmed N., Hamanaka, Kohei, Tsuboi, Takashi, Sengoku, Toru, Ogata, Kazuhiro, Iwata, Nakao, Ikeda, Masashi, Matsumoto, Naomichi, Kato, Tadafumi, Takata, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213845/
https://www.ncbi.nlm.nih.gov/pubmed/34145229
http://dx.doi.org/10.1038/s41467-021-23453-w

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