Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds

Although impaired keratinocyte migration is a recognized hallmark of chronic wounds, the molecular mechanisms underpinning impaired cell movement are poorly understood. Here, we demonstrate that both diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) exhibit global deregulation of cytoskeletal...

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Detalles Bibliográficos
Autores principales: Jozic, Ivan, Abujamra, Beatriz Abdo, Elliott, Michael H., Wikramanayake, Tongyu C., Marjanovic, Jelena, Stone, Rivka C., Head, Cheyanne R., Pastar, Irena, Kirsner, Robert S., Andreopoulos, Fotios M., Musi, Juan P., Tomic-Canic, Marjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213848/
https://www.ncbi.nlm.nih.gov/pubmed/34145387
http://dx.doi.org/10.1038/s42003-021-02298-5

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