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Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging

Recently, few noninvasive methods have been reported to evaluate endometrial fibrosis. Our study was to investigate the feasibility of intravoxel incoherent motion (IVIM) MR imaging in the detection of endometrial fibrosis in patients with intrauterine injury. 30 patients with hysteroscopy-confirmed...

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Autores principales: Hu, Qing, Jiang, Peipei, Feng, Yongjing, Xu, Yan, Zhou, Nan, Chen, Weibo, Zhu, Li, Hu, Yali, Zhou, Zhengyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213850/
https://www.ncbi.nlm.nih.gov/pubmed/34145361
http://dx.doi.org/10.1038/s41598-021-92383-w
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author Hu, Qing
Jiang, Peipei
Feng, Yongjing
Xu, Yan
Zhou, Nan
Chen, Weibo
Zhu, Li
Hu, Yali
Zhou, Zhengyang
author_facet Hu, Qing
Jiang, Peipei
Feng, Yongjing
Xu, Yan
Zhou, Nan
Chen, Weibo
Zhu, Li
Hu, Yali
Zhou, Zhengyang
author_sort Hu, Qing
collection PubMed
description Recently, few noninvasive methods have been reported to evaluate endometrial fibrosis. Our study was to investigate the feasibility of intravoxel incoherent motion (IVIM) MR imaging in the detection of endometrial fibrosis in patients with intrauterine injury. 30 patients with hysteroscopy-confirmed endometrial fibrosis and 28 healthy women were enrolled to undergo MR examination including the IVIM sequence. Endometrial thickness (ET); apparent diffusion coefficient (ADC); and IVIM parameters, including pure diffusion coefficient (D), pseudodiffusion coefficient (D*) and vascular fraction (f) were evaluated. A multivariable model combing ADC, D, and f values using binary logistic regression analysis was built to diagnose endometrial fibrosis. Endometrial fibrosis patients demonstrated lower endometrial ADC, D, f values and ET (all p < 0.05). The multivariable model, ADC, D, f values and ET performed well in diagnosing endometrial fibrosis with AUC of 0.979, 0.965, 0.920, 0.901 and 0.833, respectively. The multivariable model revealed a better diagnostic accuracy than D, f and ET (all p < 0.05). Although ADC achieved a better diagnostic value than ET (z = 2.082, p < 0.05), no difference in AUC was shown among ADC, D, and f (all p > 0.05); between ET and D (p > 0.05); and between ET and f (p > 0.05). The reproducibility of ADC, D, f and D* values in patients with endometrial fibrosis and healthy women were good to excellent (ICC: 0.614–0.951). IVIM parameters exhibit promising potential to serve as imaging biomarkers in the noninvasive assessment of endometrial fibrosis.
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spelling pubmed-82138502021-06-22 Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging Hu, Qing Jiang, Peipei Feng, Yongjing Xu, Yan Zhou, Nan Chen, Weibo Zhu, Li Hu, Yali Zhou, Zhengyang Sci Rep Article Recently, few noninvasive methods have been reported to evaluate endometrial fibrosis. Our study was to investigate the feasibility of intravoxel incoherent motion (IVIM) MR imaging in the detection of endometrial fibrosis in patients with intrauterine injury. 30 patients with hysteroscopy-confirmed endometrial fibrosis and 28 healthy women were enrolled to undergo MR examination including the IVIM sequence. Endometrial thickness (ET); apparent diffusion coefficient (ADC); and IVIM parameters, including pure diffusion coefficient (D), pseudodiffusion coefficient (D*) and vascular fraction (f) were evaluated. A multivariable model combing ADC, D, and f values using binary logistic regression analysis was built to diagnose endometrial fibrosis. Endometrial fibrosis patients demonstrated lower endometrial ADC, D, f values and ET (all p < 0.05). The multivariable model, ADC, D, f values and ET performed well in diagnosing endometrial fibrosis with AUC of 0.979, 0.965, 0.920, 0.901 and 0.833, respectively. The multivariable model revealed a better diagnostic accuracy than D, f and ET (all p < 0.05). Although ADC achieved a better diagnostic value than ET (z = 2.082, p < 0.05), no difference in AUC was shown among ADC, D, and f (all p > 0.05); between ET and D (p > 0.05); and between ET and f (p > 0.05). The reproducibility of ADC, D, f and D* values in patients with endometrial fibrosis and healthy women were good to excellent (ICC: 0.614–0.951). IVIM parameters exhibit promising potential to serve as imaging biomarkers in the noninvasive assessment of endometrial fibrosis. Nature Publishing Group UK 2021-06-18 /pmc/articles/PMC8213850/ /pubmed/34145361 http://dx.doi.org/10.1038/s41598-021-92383-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hu, Qing
Jiang, Peipei
Feng, Yongjing
Xu, Yan
Zhou, Nan
Chen, Weibo
Zhu, Li
Hu, Yali
Zhou, Zhengyang
Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging
title Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging
title_full Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging
title_fullStr Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging
title_full_unstemmed Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging
title_short Noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion MR imaging
title_sort noninvasive assessment of endometrial fibrosis in patients with intravoxel incoherent motion mr imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213850/
https://www.ncbi.nlm.nih.gov/pubmed/34145361
http://dx.doi.org/10.1038/s41598-021-92383-w
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