IgG Antibody Responses Are Preferential Compared With IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection

To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and...

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Autores principales: Longley, Rhea J, White, Michael T, Brewster, Jessica, Liu, Zoe S J, Bourke, Caitlin, Takashima, Eizo, Harbers, Matthias, Tham, Wai-Hong, Healer, Julie, Chitnis, Chetan E, Monteiro, Wuelton, Lacerda, Marcus, Sattabongkot, Jetsumon, Tsuboi, Takafumi, Mueller, Ivo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214013/
https://www.ncbi.nlm.nih.gov/pubmed/34159216
http://dx.doi.org/10.1093/ofid/ofab228
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author Longley, Rhea J
White, Michael T
Brewster, Jessica
Liu, Zoe S J
Bourke, Caitlin
Takashima, Eizo
Harbers, Matthias
Tham, Wai-Hong
Healer, Julie
Chitnis, Chetan E
Monteiro, Wuelton
Lacerda, Marcus
Sattabongkot, Jetsumon
Tsuboi, Takafumi
Mueller, Ivo
author_facet Longley, Rhea J
White, Michael T
Brewster, Jessica
Liu, Zoe S J
Bourke, Caitlin
Takashima, Eizo
Harbers, Matthias
Tham, Wai-Hong
Healer, Julie
Chitnis, Chetan E
Monteiro, Wuelton
Lacerda, Marcus
Sattabongkot, Jetsumon
Tsuboi, Takafumi
Mueller, Ivo
author_sort Longley, Rhea J
collection PubMed
description To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, immunoglobulin M (IgM) in addition to immunoglobulin G (IgG) antibody responses were compared with a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG.
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spelling pubmed-82140132021-06-21 IgG Antibody Responses Are Preferential Compared With IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection Longley, Rhea J White, Michael T Brewster, Jessica Liu, Zoe S J Bourke, Caitlin Takashima, Eizo Harbers, Matthias Tham, Wai-Hong Healer, Julie Chitnis, Chetan E Monteiro, Wuelton Lacerda, Marcus Sattabongkot, Jetsumon Tsuboi, Takafumi Mueller, Ivo Open Forum Infect Dis Brief Reports To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, immunoglobulin M (IgM) in addition to immunoglobulin G (IgG) antibody responses were compared with a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG. Oxford University Press 2021-05-22 /pmc/articles/PMC8214013/ /pubmed/34159216 http://dx.doi.org/10.1093/ofid/ofab228 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Longley, Rhea J
White, Michael T
Brewster, Jessica
Liu, Zoe S J
Bourke, Caitlin
Takashima, Eizo
Harbers, Matthias
Tham, Wai-Hong
Healer, Julie
Chitnis, Chetan E
Monteiro, Wuelton
Lacerda, Marcus
Sattabongkot, Jetsumon
Tsuboi, Takafumi
Mueller, Ivo
IgG Antibody Responses Are Preferential Compared With IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection
title IgG Antibody Responses Are Preferential Compared With IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection
title_full IgG Antibody Responses Are Preferential Compared With IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection
title_fullStr IgG Antibody Responses Are Preferential Compared With IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection
title_full_unstemmed IgG Antibody Responses Are Preferential Compared With IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection
title_short IgG Antibody Responses Are Preferential Compared With IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection
title_sort igg antibody responses are preferential compared with igm for use as serological markers for detecting recent exposure to plasmodium vivax infection
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214013/
https://www.ncbi.nlm.nih.gov/pubmed/34159216
http://dx.doi.org/10.1093/ofid/ofab228
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