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Altered expression of microRNAs and B lymphocytes during Natalizumab therapy in multiple sclerosis
MicroRNAs (miRNAs) are a family of non-translated small ribonucleic acids (RNAs) measuring 21–25 nucleotides in length that play various roles in multiple sclerosis (MS). By regulating gene expression via either mediating translational repression or cleavage of the target RNA, miRNAs can alter the e...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214090/ https://www.ncbi.nlm.nih.gov/pubmed/34179535 http://dx.doi.org/10.1016/j.heliyon.2021.e07263 |
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author | Franzoi, André Eduardo de Almeida de Moraes Machado, Fernanda Subtil de Medeiros Junior, Washigton Luiz Gomes Bandeira, Isabelle Pastor Brandão, Wesley Nogueira Gonçalves, Marcus Vinicius Magno |
author_facet | Franzoi, André Eduardo de Almeida de Moraes Machado, Fernanda Subtil de Medeiros Junior, Washigton Luiz Gomes Bandeira, Isabelle Pastor Brandão, Wesley Nogueira Gonçalves, Marcus Vinicius Magno |
author_sort | Franzoi, André Eduardo de Almeida |
collection | PubMed |
description | MicroRNAs (miRNAs) are a family of non-translated small ribonucleic acids (RNAs) measuring 21–25 nucleotides in length that play various roles in multiple sclerosis (MS). By regulating gene expression via either mediating translational repression or cleavage of the target RNA, miRNAs can alter the expression of transcripts in different cells, such as B lymphocytes, also known as B cells. They are crucial in the pathogenesis of MS; however, they have not been extensively studied during the treatment of some drugs such as natalizumab (NTZ). NTZ is a humanized immunoglobulin G4 antibody antagonist for integrin alpha 4 (α4) used in the treatment of MS. The drug reduces the homing of lymphocytes to inflammation sites. Integrin α4 expression on the cell surface of B cells is related to MS severity, indicating a critical component in the pathogenesis of the disease. NTZ plays an important role in modifying the gene expression in B cells and the levels of miRNAs in the treatment of MS. In this review, we have described changes in gene expression in B cells and the levels of miRNAs during NTZ therapy in MS and its relapse. Studies using the experimental autoimmune encephalomyelitis (EAE) model and those involving patients with MS have described changes in the levels of microRNAs in the regulation of proteins affected by specific miRNAs, gene expression in B cells, and certain functions of B cells as well as their subpopulations. Therefore, there is a possibility that some miRNAs could be studied at different stages of MS during NTZ treatment, and these specific miRNAs can be tested as markers of therapeutic response to this drug in future studies. Physiopathology, gene expression in B cells and their subpopulations can help understand this complex puzzle involving miRNAs and the therapeutic response of patients with MS. |
format | Online Article Text |
id | pubmed-8214090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-82140902021-06-25 Altered expression of microRNAs and B lymphocytes during Natalizumab therapy in multiple sclerosis Franzoi, André Eduardo de Almeida de Moraes Machado, Fernanda Subtil de Medeiros Junior, Washigton Luiz Gomes Bandeira, Isabelle Pastor Brandão, Wesley Nogueira Gonçalves, Marcus Vinicius Magno Heliyon Review Article MicroRNAs (miRNAs) are a family of non-translated small ribonucleic acids (RNAs) measuring 21–25 nucleotides in length that play various roles in multiple sclerosis (MS). By regulating gene expression via either mediating translational repression or cleavage of the target RNA, miRNAs can alter the expression of transcripts in different cells, such as B lymphocytes, also known as B cells. They are crucial in the pathogenesis of MS; however, they have not been extensively studied during the treatment of some drugs such as natalizumab (NTZ). NTZ is a humanized immunoglobulin G4 antibody antagonist for integrin alpha 4 (α4) used in the treatment of MS. The drug reduces the homing of lymphocytes to inflammation sites. Integrin α4 expression on the cell surface of B cells is related to MS severity, indicating a critical component in the pathogenesis of the disease. NTZ plays an important role in modifying the gene expression in B cells and the levels of miRNAs in the treatment of MS. In this review, we have described changes in gene expression in B cells and the levels of miRNAs during NTZ therapy in MS and its relapse. Studies using the experimental autoimmune encephalomyelitis (EAE) model and those involving patients with MS have described changes in the levels of microRNAs in the regulation of proteins affected by specific miRNAs, gene expression in B cells, and certain functions of B cells as well as their subpopulations. Therefore, there is a possibility that some miRNAs could be studied at different stages of MS during NTZ treatment, and these specific miRNAs can be tested as markers of therapeutic response to this drug in future studies. Physiopathology, gene expression in B cells and their subpopulations can help understand this complex puzzle involving miRNAs and the therapeutic response of patients with MS. Elsevier 2021-06-09 /pmc/articles/PMC8214090/ /pubmed/34179535 http://dx.doi.org/10.1016/j.heliyon.2021.e07263 Text en © 2021 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Franzoi, André Eduardo de Almeida de Moraes Machado, Fernanda Subtil de Medeiros Junior, Washigton Luiz Gomes Bandeira, Isabelle Pastor Brandão, Wesley Nogueira Gonçalves, Marcus Vinicius Magno Altered expression of microRNAs and B lymphocytes during Natalizumab therapy in multiple sclerosis |
title | Altered expression of microRNAs and B lymphocytes during Natalizumab therapy in multiple sclerosis |
title_full | Altered expression of microRNAs and B lymphocytes during Natalizumab therapy in multiple sclerosis |
title_fullStr | Altered expression of microRNAs and B lymphocytes during Natalizumab therapy in multiple sclerosis |
title_full_unstemmed | Altered expression of microRNAs and B lymphocytes during Natalizumab therapy in multiple sclerosis |
title_short | Altered expression of microRNAs and B lymphocytes during Natalizumab therapy in multiple sclerosis |
title_sort | altered expression of micrornas and b lymphocytes during natalizumab therapy in multiple sclerosis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214090/ https://www.ncbi.nlm.nih.gov/pubmed/34179535 http://dx.doi.org/10.1016/j.heliyon.2021.e07263 |
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