Cargando…

Exhaled Nitric Oxide as a Surrogate Marker for Obstructive Sleep Apnea Severity Grading: An In-Hospital Population Study

PURPOSE: Our study aimed to evaluate the relationship between exhaled nitric oxide (eNO) markers and obstructive sleep apnea (OSA) severity and verify the changes in eNO profiles among mild, moderate, and severe OSA subgroups. METHODS: This study was a cross-sectional and in-hospital population-base...

Descripción completa

Detalles Bibliográficos
Autores principales: Dang-Thi-Mai, Khue, Le-Dong, Nhat-Nam, Le-Thuong, Vu, Tran-Van, Ngoc, Duong-Quy, Sy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214111/
https://www.ncbi.nlm.nih.gov/pubmed/34163272
http://dx.doi.org/10.2147/NSS.S307012
_version_ 1783709993434873856
author Dang-Thi-Mai, Khue
Le-Dong, Nhat-Nam
Le-Thuong, Vu
Tran-Van, Ngoc
Duong-Quy, Sy
author_facet Dang-Thi-Mai, Khue
Le-Dong, Nhat-Nam
Le-Thuong, Vu
Tran-Van, Ngoc
Duong-Quy, Sy
author_sort Dang-Thi-Mai, Khue
collection PubMed
description PURPOSE: Our study aimed to evaluate the relationship between exhaled nitric oxide (eNO) markers and obstructive sleep apnea (OSA) severity and verify the changes in eNO profiles among mild, moderate, and severe OSA subgroups. METHODS: This study was a cross-sectional and in-hospital population-based study. We investigated 123 OSA patients (17 mild, 23 moderate and, 83 severe OSA) in the department of respiratory diseases. Studied data included anthropometry, respiratory polygraphy, biological markers, spirometry, and multi-flow eNO measurements. Data analysis implied linear correlation, non-parametric ANOVA, and pair-wise comparison. RESULTS: No significant difference could be found among 3 OSA severity subgroups for FENO at – four sampling flow rates (50–350 mL/s). The bronchial production rate of NO (J’awNO) was proportionally increased, with median values of 11.2, 33.9, and 36.2 in mild, moderate, and severe OSA, respectively (p=0.010). The alveolar concentration of NO (CANO) changed with a non-linear pattern; it was increased in moderate (6.49) vs mild (7.79) OSA but decreased in severe OSA (5.20, p = 0.015). The only correction that could be established between OSA severity and exhaled nitric oxide markers is through J’AWNO (rho=0.25, p=0.02) and CANO (rho= 0.18, p=0.04). There was no significant correlation between FENO measured at three different flow rates and the OSA severity. We also found a weak but significant correlation between FENO 100 and averaged SpO2 (rho = 0.07, p= 0.03). CONCLUSION: The present study showed that J’AWNO, which represents eNO derived from the central airway, is proportionally increased in more severe OSA, while eNO from alveolar space, indicated by CANO, was also associated with OSA severity and relatively lower in the most severe OSA patients. In contrast, stand-alone FENO metrics did not show a clear difference among the three severity subgroups.
format Online
Article
Text
id pubmed-8214111
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-82141112021-06-22 Exhaled Nitric Oxide as a Surrogate Marker for Obstructive Sleep Apnea Severity Grading: An In-Hospital Population Study Dang-Thi-Mai, Khue Le-Dong, Nhat-Nam Le-Thuong, Vu Tran-Van, Ngoc Duong-Quy, Sy Nat Sci Sleep Original Research PURPOSE: Our study aimed to evaluate the relationship between exhaled nitric oxide (eNO) markers and obstructive sleep apnea (OSA) severity and verify the changes in eNO profiles among mild, moderate, and severe OSA subgroups. METHODS: This study was a cross-sectional and in-hospital population-based study. We investigated 123 OSA patients (17 mild, 23 moderate and, 83 severe OSA) in the department of respiratory diseases. Studied data included anthropometry, respiratory polygraphy, biological markers, spirometry, and multi-flow eNO measurements. Data analysis implied linear correlation, non-parametric ANOVA, and pair-wise comparison. RESULTS: No significant difference could be found among 3 OSA severity subgroups for FENO at – four sampling flow rates (50–350 mL/s). The bronchial production rate of NO (J’awNO) was proportionally increased, with median values of 11.2, 33.9, and 36.2 in mild, moderate, and severe OSA, respectively (p=0.010). The alveolar concentration of NO (CANO) changed with a non-linear pattern; it was increased in moderate (6.49) vs mild (7.79) OSA but decreased in severe OSA (5.20, p = 0.015). The only correction that could be established between OSA severity and exhaled nitric oxide markers is through J’AWNO (rho=0.25, p=0.02) and CANO (rho= 0.18, p=0.04). There was no significant correlation between FENO measured at three different flow rates and the OSA severity. We also found a weak but significant correlation between FENO 100 and averaged SpO2 (rho = 0.07, p= 0.03). CONCLUSION: The present study showed that J’AWNO, which represents eNO derived from the central airway, is proportionally increased in more severe OSA, while eNO from alveolar space, indicated by CANO, was also associated with OSA severity and relatively lower in the most severe OSA patients. In contrast, stand-alone FENO metrics did not show a clear difference among the three severity subgroups. Dove 2021-06-14 /pmc/articles/PMC8214111/ /pubmed/34163272 http://dx.doi.org/10.2147/NSS.S307012 Text en © 2021 Dang-Thi-Mai et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Dang-Thi-Mai, Khue
Le-Dong, Nhat-Nam
Le-Thuong, Vu
Tran-Van, Ngoc
Duong-Quy, Sy
Exhaled Nitric Oxide as a Surrogate Marker for Obstructive Sleep Apnea Severity Grading: An In-Hospital Population Study
title Exhaled Nitric Oxide as a Surrogate Marker for Obstructive Sleep Apnea Severity Grading: An In-Hospital Population Study
title_full Exhaled Nitric Oxide as a Surrogate Marker for Obstructive Sleep Apnea Severity Grading: An In-Hospital Population Study
title_fullStr Exhaled Nitric Oxide as a Surrogate Marker for Obstructive Sleep Apnea Severity Grading: An In-Hospital Population Study
title_full_unstemmed Exhaled Nitric Oxide as a Surrogate Marker for Obstructive Sleep Apnea Severity Grading: An In-Hospital Population Study
title_short Exhaled Nitric Oxide as a Surrogate Marker for Obstructive Sleep Apnea Severity Grading: An In-Hospital Population Study
title_sort exhaled nitric oxide as a surrogate marker for obstructive sleep apnea severity grading: an in-hospital population study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214111/
https://www.ncbi.nlm.nih.gov/pubmed/34163272
http://dx.doi.org/10.2147/NSS.S307012
work_keys_str_mv AT dangthimaikhue exhalednitricoxideasasurrogatemarkerforobstructivesleepapneaseveritygradinganinhospitalpopulationstudy
AT ledongnhatnam exhalednitricoxideasasurrogatemarkerforobstructivesleepapneaseveritygradinganinhospitalpopulationstudy
AT lethuongvu exhalednitricoxideasasurrogatemarkerforobstructivesleepapneaseveritygradinganinhospitalpopulationstudy
AT tranvanngoc exhalednitricoxideasasurrogatemarkerforobstructivesleepapneaseveritygradinganinhospitalpopulationstudy
AT duongquysy exhalednitricoxideasasurrogatemarkerforobstructivesleepapneaseveritygradinganinhospitalpopulationstudy