Cargando…

Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the Bordetella adenylate cyclase toxin

The whooping cough agent Bordetella pertussis secretes an adenylate cyclase toxin (CyaA) that through its large carboxy-proximal Repeat-in-ToXin (RTX) domain binds the complement receptor 3 (CR3). The RTX domain consists of five blocks (I–V) of characteristic glycine and aspartate-rich nonapeptides...

Descripción completa

Detalles Bibliográficos
Autores principales:	Espinosa-Vinals, Carlos Angel, Masin, Jiri, Holubova, Jana, Stanek, Ondrej, Jurnecka, David, Osicka, Radim, Sebo, Peter, Bumba, Ladislav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214218/ https://www.ncbi.nlm.nih.gov/pubmed/34051233 http://dx.doi.org/10.1016/j.jbc.2021.100833

Ejemplares similares

Selective Enhancement of the Cell-Permeabilizing Activity of Adenylate Cyclase Toxin Does Not Increase Virulence of Bordetella pertussis
por: Holubova, Jana, et al.
Publicado: (2021)

Structure–Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes
por: Novak, Jakub, et al.
Publicado: (2017)

Bordetella Pertussis Adenylate Cyclase Toxin Does Not Possess a Phospholipase A Activity; Serine 606 and Aspartate 1079 Residues Are Not Involved in Target Cell Delivery of the Adenylyl Cyclase Enzyme Domain
por: Bumba, Ladislav, et al.
Publicado: (2018)

Rapid Purification of Endotoxin-Free RTX Toxins
por: Stanek, Ondrej, et al.
Publicado: (2019)

Different roles of conserved tyrosine residues of the acylated domains in folding and activity of RTX toxins
por: Lepesheva, Anna, et al.
Publicado: (2021)

Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3
por: Osicka, Radim, et al.
Publicado: (2015)

The conserved tyrosine residue 940 plays a key structural role in membrane interaction of Bordetella adenylate cyclase toxin
por: Masin, Jiri, et al.
Publicado: (2017)

The adenylate cyclase toxin RTX domain follows a series templated folding mechanism with implications for toxin activity
por: Chen, Guojun, et al.
Publicado: (2023)

Bordetella Adenylate Cyclase Toxin Mobilizes Its β(2) Integrin Receptor into Lipid Rafts to Accomplish Translocation across Target Cell Membrane in Two Steps
por: Bumba, Ladislav, et al.
Publicado: (2010)

Residues 529 to 549 participate in membrane penetration and pore-forming activity of the Bordetella adenylate cyclase toxin
por: Roderova, Jana, et al.
Publicado: (2019)

Negatively charged residues of the segment linking the enzyme and cytolysin moieties restrict the membrane-permeabilizing capacity of adenylate cyclase toxin
por: Masin, Jiri, et al.
Publicado: (2016)

RTX proteins: a highly diverse family secreted by a common mechanism
por: Linhartová, Irena, et al.
Publicado: (2010)

Production of Highly Active Recombinant Dermonecrotic Toxin of Bordetella Pertussis
por: Stanek, Ondrej, et al.
Publicado: (2020)

Bordetella Adenylate Cyclase Toxin Elicits Airway Mucin Secretion through Activation of the cAMP Response Element Binding Protein
por: Malandra, Anna, et al.
Publicado: (2021)

Bordetella pertussis and Bordetella bronchiseptica filamentous hemagglutinins are processed at different sites
por: Jurnecka, David, et al.
Publicado: (2018)

Acellular Pertussis Vaccine Inhibits Bordetella pertussis Clearance from the Nasal Mucosa of Mice
por: Holubová, Jana, et al.
Publicado: (2020)

A conserved tryptophan in the acylated segment of RTX toxins controls their β(2) integrin–independent cell penetration
por: Osickova, Adriana, et al.
Publicado: (2023)

Calcium Influx Rescues Adenylate Cyclase-Hemolysin from Rapid Cell Membrane Removal and Enables Phagocyte Permeabilization by Toxin Pores
por: Fiser, Radovan, et al.
Publicado: (2012)

Bordetella Adenylate Cyclase Toxin Differentially Modulates Toll-Like Receptor-Stimulated Activation, Migration and T Cell Stimulatory Capacity of Dendritic Cells
por: Adkins, Irena, et al.
Publicado: (2014)

Phosphoproteomics of cAMP signaling of Bordetella adenylate cyclase toxin in mouse dendritic cells
por: Novák, Jakub, et al.
Publicado: (2017)

Bordetella Adenylate Cyclase Toxin Inhibits Monocyte-to-Macrophage Transition and Dedifferentiates Human Alveolar Macrophages into Monocyte-like Cells
por: Ahmad, Jawid Nazir, et al.
Publicado: (2019)

Bordetella Adenylate Cyclase-Hemolysin Toxins
por: Guiso, Nicole
Publicado: (2017)

Block V RTX Domain of Adenylate Cyclase from Bordetella pertussis: A Conformationally Dynamic Scaffold for Protein Engineering Applications
por: Bulutoglu, Beyza, et al.
Publicado: (2017)

Simultaneous Determination of Antibodies to Pertussis Toxin and Adenylate Cyclase Toxin Improves Serological Diagnosis of Pertussis
por: Knuutila, Aapo, et al.
Publicado: (2021)

Kingella kingae RtxA Cytotoxin in the Context of Other RTX Toxins
por: Filipi, Katerina, et al.
Publicado: (2022)

Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity
por: Fedele, Giorgio, et al.
Publicado: (2017)

Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes
por: Goldsmith, Jory A., et al.
Publicado: (2021)

Templated folding of the RTX domain of the bacterial toxin adenylate cyclase revealed by single molecule force spectroscopy
por: Wang, Han, et al.
Publicado: (2022)

Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy
por: Chenal, Alexandre, et al.
Publicado: (2018)

Filamentous Hemagglutinin of Bordetella pertussis Does Not Interact with the β(2) Integrin CD11b/CD18
por: Golshani, Maryam, et al.
Publicado: (2022)

Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation
por: Ahmad, Jawid Nazir, et al.
Publicado: (2020)

Membrane Permeabilization by Bordetella Adenylate Cyclase Toxin Involves Pores of Tunable Size
por: González-Bullón, David, et al.
Publicado: (2019)

Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin
por: Goldsmith, Jory A., et al.
Publicado: (2022)

A Mutation Upstream of the rplN-rpsD Ribosomal Operon Downregulates Bordetella pertussis Virulence Factor Production without Compromising Bacterial Survival within Human Macrophages
por: Novák, Jakub, et al.
Publicado: (2020)

Pertussis toxin suppresses dendritic cell-mediated delivery of B. pertussis into lung-draining lymph nodes
por: Klimova, Nela, et al.
Publicado: (2022)

Characterization of the Intrinsic Phospholipase A1 Activity of Bordetella pertussis Adenylate Cyclase Toxin
por: González-Bullón, David, et al.
Publicado: (2018)

Functional and structural consequences of epithelial cell invasion by Bordetella pertussis adenylate cyclase toxin
por: Angely, Christelle, et al.
Publicado: (2020)

Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes
por: Ladant, Daniel
Publicado: (2021)

Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue
por: Bayram, Jan, et al.
Publicado: (2020)

Characterization of Post-Translational Modifications and Cytotoxic Properties of the Adenylate-Cyclase Hemolysin Produced by Various Bordetella pertussis and Bordetella parapertussis Isolates
por: Bouchez, Valérie, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tltgu9peo81ihbvulshpcnbr4c