Sequence determinants in the cathelicidin LL-37 that promote inflammation via presentation of RNA to scavenger receptors

Cathelicidins such as the human 37-amino acid peptide (LL-37) are peptides that not only potently kill microbes but also trigger inflammation by enabling immune recognition of endogenous nucleic acids. Here, a detailed structure–function analysis of LL-37 was performed to understand the details of t...

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Detalles Bibliográficos
Autores principales: Kulkarni, Nikhil N., O’Neill, Alan M., Dokoshi, Tatsuya, Luo, Elizabeth W.C., Wong, Gerard C.L., Gallo, Richard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214221/
https://www.ncbi.nlm.nih.gov/pubmed/34048712
http://dx.doi.org/10.1016/j.jbc.2021.100828

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