A recombinant receptor-binding domain in trimeric form generates protective immunity against SARS-CoV-2 infection in nonhuman primates

A safe and effective vaccine is critical to combat the COVID-19 pandemic. Here, we developed a trimeric SARS-CoV-2 receptor-binding domain (RBD) subunit vaccine candidate that simulates the natural structure of the spike (S) trimer glycoprotein. Immunization with the RBD trimer-induced robust humora...

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Detalles Bibliográficos
Autores principales: Yang, Limin, Tian, Deyu, Han, Jian-bao, Fan, Wenhui, Zhang, Yuan, Li, Yunlong, Sun, Wenqiang, Wei, Yanqiu, Tian, Xiaodong, Yu, Dan-dan, Feng, Xiao-li, Cheng, Gong, Bi, Yuhai, Zheng, Yong-tang, Liu, Wenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214323/
https://www.ncbi.nlm.nih.gov/pubmed/34179862
http://dx.doi.org/10.1016/j.xinn.2021.100140

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