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History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study

OBJECTIVES: A history of severe hypoglycemia (SH) is associated with cardiovascular (CV) events among patients with type 2 diabetes mellitus (T2DM). In this study, we compared the severity of atherosclerotic coronary artery disease (ACAD) in T2DM patients with and without a history of SH. METHODOLOG...

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Autores principales: Raffali, Mohd Asyiq, Muhammad, Syawal Faizal, Hamid, Hamzaini Abdul, Nawi, Azmawati Mohammed, Kamaruddin, Nor Azmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of the ASEAN Federation of Endocrine Societies 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214343/
https://www.ncbi.nlm.nih.gov/pubmed/34177086
http://dx.doi.org/10.15605/jafes.036.01.15
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author Raffali, Mohd Asyiq
Muhammad, Syawal Faizal
Hamid, Hamzaini Abdul
Nawi, Azmawati Mohammed
Kamaruddin, Nor Azmi
author_facet Raffali, Mohd Asyiq
Muhammad, Syawal Faizal
Hamid, Hamzaini Abdul
Nawi, Azmawati Mohammed
Kamaruddin, Nor Azmi
author_sort Raffali, Mohd Asyiq
collection PubMed
description OBJECTIVES: A history of severe hypoglycemia (SH) is associated with cardiovascular (CV) events among patients with type 2 diabetes mellitus (T2DM). In this study, we compared the severity of atherosclerotic coronary artery disease (ACAD) in T2DM patients with and without a history of SH. METHODOLOGY: We conducted a comparative case-control study involving 28 T2DM patients with a history of SH within the last 5 years with no documented ACAD, and matched them with 28 T2DM patients with no history of SH. All subjects underwent coronary artery calcium scoring (CACS) with or without coronary computed tomographic angiography (CCTA) to evaluate the severity of ACAD. RESULTS: A history of SH in T2DM was associated with a higher prevalence of significant ACAD (79% versus 46%, p=0.026). A high CACS (≥100) was seen in a greater number of patients with a history of SH compared to those without (75% versus 43%, p=0.029). Similarly, there was a higher prevalence of obstructive CAD in those with a history of SH compared to those without (72% versus 39%, p=0.036). Median C-reactive protein level was also higher among patients with a history of SH (0.41 mg/dL versus 0.16 mg/dL, p=0.029). CONCLUSION: In patients with T2DM, a history of SH is significantly associated with ACAD compared to those without SH. A history of SH warrants screening for ACAD.
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spelling pubmed-82143432021-06-25 History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study Raffali, Mohd Asyiq Muhammad, Syawal Faizal Hamid, Hamzaini Abdul Nawi, Azmawati Mohammed Kamaruddin, Nor Azmi J ASEAN Fed Endocr Soc Original Article OBJECTIVES: A history of severe hypoglycemia (SH) is associated with cardiovascular (CV) events among patients with type 2 diabetes mellitus (T2DM). In this study, we compared the severity of atherosclerotic coronary artery disease (ACAD) in T2DM patients with and without a history of SH. METHODOLOGY: We conducted a comparative case-control study involving 28 T2DM patients with a history of SH within the last 5 years with no documented ACAD, and matched them with 28 T2DM patients with no history of SH. All subjects underwent coronary artery calcium scoring (CACS) with or without coronary computed tomographic angiography (CCTA) to evaluate the severity of ACAD. RESULTS: A history of SH in T2DM was associated with a higher prevalence of significant ACAD (79% versus 46%, p=0.026). A high CACS (≥100) was seen in a greater number of patients with a history of SH compared to those without (75% versus 43%, p=0.029). Similarly, there was a higher prevalence of obstructive CAD in those with a history of SH compared to those without (72% versus 39%, p=0.036). Median C-reactive protein level was also higher among patients with a history of SH (0.41 mg/dL versus 0.16 mg/dL, p=0.029). CONCLUSION: In patients with T2DM, a history of SH is significantly associated with ACAD compared to those without SH. A history of SH warrants screening for ACAD. Journal of the ASEAN Federation of Endocrine Societies 2021-05-07 2021 /pmc/articles/PMC8214343/ /pubmed/34177086 http://dx.doi.org/10.15605/jafes.036.01.15 Text en © 2021 Journal of the ASEAN Federation of Endocrine Societies https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International.
spellingShingle Original Article
Raffali, Mohd Asyiq
Muhammad, Syawal Faizal
Hamid, Hamzaini Abdul
Nawi, Azmawati Mohammed
Kamaruddin, Nor Azmi
History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study
title History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study
title_full History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study
title_fullStr History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study
title_full_unstemmed History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study
title_short History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study
title_sort history of severe hypoglycemia in type 2 diabetes mellitus unmasked significant atherosclerotic coronary artery disease: a comparative case control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214343/
https://www.ncbi.nlm.nih.gov/pubmed/34177086
http://dx.doi.org/10.15605/jafes.036.01.15
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