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History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study
OBJECTIVES: A history of severe hypoglycemia (SH) is associated with cardiovascular (CV) events among patients with type 2 diabetes mellitus (T2DM). In this study, we compared the severity of atherosclerotic coronary artery disease (ACAD) in T2DM patients with and without a history of SH. METHODOLOG...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Journal of the ASEAN Federation of Endocrine Societies
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214343/ https://www.ncbi.nlm.nih.gov/pubmed/34177086 http://dx.doi.org/10.15605/jafes.036.01.15 |
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author | Raffali, Mohd Asyiq Muhammad, Syawal Faizal Hamid, Hamzaini Abdul Nawi, Azmawati Mohammed Kamaruddin, Nor Azmi |
author_facet | Raffali, Mohd Asyiq Muhammad, Syawal Faizal Hamid, Hamzaini Abdul Nawi, Azmawati Mohammed Kamaruddin, Nor Azmi |
author_sort | Raffali, Mohd Asyiq |
collection | PubMed |
description | OBJECTIVES: A history of severe hypoglycemia (SH) is associated with cardiovascular (CV) events among patients with type 2 diabetes mellitus (T2DM). In this study, we compared the severity of atherosclerotic coronary artery disease (ACAD) in T2DM patients with and without a history of SH. METHODOLOGY: We conducted a comparative case-control study involving 28 T2DM patients with a history of SH within the last 5 years with no documented ACAD, and matched them with 28 T2DM patients with no history of SH. All subjects underwent coronary artery calcium scoring (CACS) with or without coronary computed tomographic angiography (CCTA) to evaluate the severity of ACAD. RESULTS: A history of SH in T2DM was associated with a higher prevalence of significant ACAD (79% versus 46%, p=0.026). A high CACS (≥100) was seen in a greater number of patients with a history of SH compared to those without (75% versus 43%, p=0.029). Similarly, there was a higher prevalence of obstructive CAD in those with a history of SH compared to those without (72% versus 39%, p=0.036). Median C-reactive protein level was also higher among patients with a history of SH (0.41 mg/dL versus 0.16 mg/dL, p=0.029). CONCLUSION: In patients with T2DM, a history of SH is significantly associated with ACAD compared to those without SH. A history of SH warrants screening for ACAD. |
format | Online Article Text |
id | pubmed-8214343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Journal of the ASEAN Federation of Endocrine Societies |
record_format | MEDLINE/PubMed |
spelling | pubmed-82143432021-06-25 History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study Raffali, Mohd Asyiq Muhammad, Syawal Faizal Hamid, Hamzaini Abdul Nawi, Azmawati Mohammed Kamaruddin, Nor Azmi J ASEAN Fed Endocr Soc Original Article OBJECTIVES: A history of severe hypoglycemia (SH) is associated with cardiovascular (CV) events among patients with type 2 diabetes mellitus (T2DM). In this study, we compared the severity of atherosclerotic coronary artery disease (ACAD) in T2DM patients with and without a history of SH. METHODOLOGY: We conducted a comparative case-control study involving 28 T2DM patients with a history of SH within the last 5 years with no documented ACAD, and matched them with 28 T2DM patients with no history of SH. All subjects underwent coronary artery calcium scoring (CACS) with or without coronary computed tomographic angiography (CCTA) to evaluate the severity of ACAD. RESULTS: A history of SH in T2DM was associated with a higher prevalence of significant ACAD (79% versus 46%, p=0.026). A high CACS (≥100) was seen in a greater number of patients with a history of SH compared to those without (75% versus 43%, p=0.029). Similarly, there was a higher prevalence of obstructive CAD in those with a history of SH compared to those without (72% versus 39%, p=0.036). Median C-reactive protein level was also higher among patients with a history of SH (0.41 mg/dL versus 0.16 mg/dL, p=0.029). CONCLUSION: In patients with T2DM, a history of SH is significantly associated with ACAD compared to those without SH. A history of SH warrants screening for ACAD. Journal of the ASEAN Federation of Endocrine Societies 2021-05-07 2021 /pmc/articles/PMC8214343/ /pubmed/34177086 http://dx.doi.org/10.15605/jafes.036.01.15 Text en © 2021 Journal of the ASEAN Federation of Endocrine Societies https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International. |
spellingShingle | Original Article Raffali, Mohd Asyiq Muhammad, Syawal Faizal Hamid, Hamzaini Abdul Nawi, Azmawati Mohammed Kamaruddin, Nor Azmi History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study |
title | History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study |
title_full | History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study |
title_fullStr | History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study |
title_full_unstemmed | History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study |
title_short | History of Severe Hypoglycemia in Type 2 Diabetes Mellitus Unmasked Significant Atherosclerotic Coronary Artery Disease: A Comparative Case Control Study |
title_sort | history of severe hypoglycemia in type 2 diabetes mellitus unmasked significant atherosclerotic coronary artery disease: a comparative case control study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214343/ https://www.ncbi.nlm.nih.gov/pubmed/34177086 http://dx.doi.org/10.15605/jafes.036.01.15 |
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