Cargando…

Bacteremia in a Newborn with Hypocalcemic Seizures and Vitamin D Deficiency

Infants with neonatal hypocalcemia often present with seizures, and neonatal hypocalcemia can be due to parathyroid (PTH) insufficiency or resistance. Causes of hypocalcemia with PTH elevation include increased phosphate load, vitamin D deficiency (VDD) or defects in metabolism, renal dysfunction, h...

Descripción completa

Detalles Bibliográficos
Autores principales: Moore, Rebecca L., Lorenz, Matthew L., Fredette, Meghan E., Topor, Lisa Swartz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214477/
https://www.ncbi.nlm.nih.gov/pubmed/34194851
http://dx.doi.org/10.1155/2021/9925707
_version_ 1783710070690807808
author Moore, Rebecca L.
Lorenz, Matthew L.
Fredette, Meghan E.
Topor, Lisa Swartz
author_facet Moore, Rebecca L.
Lorenz, Matthew L.
Fredette, Meghan E.
Topor, Lisa Swartz
author_sort Moore, Rebecca L.
collection PubMed
description Infants with neonatal hypocalcemia often present with seizures, and neonatal hypocalcemia can be due to parathyroid (PTH) insufficiency or resistance. Causes of hypocalcemia with PTH elevation include increased phosphate load, vitamin D deficiency (VDD) or defects in metabolism, renal dysfunction, hypomagnesemia, genetic mutations resulting in end-organ resistance to PTH, or critical illness. Hypocalcemia has also been shown to be associated with Gram-negative bacteremia and sepsis in adults. We present the case of a full-term, formula-fed newborn presenting with late-onset hypocalcemic seizures and VDD in the setting of Klebsiella pneumoniae bacteremia. This case highlights that newborns presenting with hypocalcemic seizures should undergo a workup for sepsis.
format Online
Article
Text
id pubmed-8214477
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-82144772021-06-29 Bacteremia in a Newborn with Hypocalcemic Seizures and Vitamin D Deficiency Moore, Rebecca L. Lorenz, Matthew L. Fredette, Meghan E. Topor, Lisa Swartz Case Rep Endocrinol Case Report Infants with neonatal hypocalcemia often present with seizures, and neonatal hypocalcemia can be due to parathyroid (PTH) insufficiency or resistance. Causes of hypocalcemia with PTH elevation include increased phosphate load, vitamin D deficiency (VDD) or defects in metabolism, renal dysfunction, hypomagnesemia, genetic mutations resulting in end-organ resistance to PTH, or critical illness. Hypocalcemia has also been shown to be associated with Gram-negative bacteremia and sepsis in adults. We present the case of a full-term, formula-fed newborn presenting with late-onset hypocalcemic seizures and VDD in the setting of Klebsiella pneumoniae bacteremia. This case highlights that newborns presenting with hypocalcemic seizures should undergo a workup for sepsis. Hindawi 2021-06-12 /pmc/articles/PMC8214477/ /pubmed/34194851 http://dx.doi.org/10.1155/2021/9925707 Text en Copyright © 2021 Rebecca L. Moore et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Moore, Rebecca L.
Lorenz, Matthew L.
Fredette, Meghan E.
Topor, Lisa Swartz
Bacteremia in a Newborn with Hypocalcemic Seizures and Vitamin D Deficiency
title Bacteremia in a Newborn with Hypocalcemic Seizures and Vitamin D Deficiency
title_full Bacteremia in a Newborn with Hypocalcemic Seizures and Vitamin D Deficiency
title_fullStr Bacteremia in a Newborn with Hypocalcemic Seizures and Vitamin D Deficiency
title_full_unstemmed Bacteremia in a Newborn with Hypocalcemic Seizures and Vitamin D Deficiency
title_short Bacteremia in a Newborn with Hypocalcemic Seizures and Vitamin D Deficiency
title_sort bacteremia in a newborn with hypocalcemic seizures and vitamin d deficiency
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214477/
https://www.ncbi.nlm.nih.gov/pubmed/34194851
http://dx.doi.org/10.1155/2021/9925707
work_keys_str_mv AT moorerebeccal bacteremiainanewbornwithhypocalcemicseizuresandvitaminddeficiency
AT lorenzmatthewl bacteremiainanewbornwithhypocalcemicseizuresandvitaminddeficiency
AT fredettemeghane bacteremiainanewbornwithhypocalcemicseizuresandvitaminddeficiency
AT toporlisaswartz bacteremiainanewbornwithhypocalcemicseizuresandvitaminddeficiency