Cargando…

The Relationship between Serum Procalcitonin and Dialysis Adequacy in Peritoneal Dialysis Patients

BACKGROUND: To detect the serum procalcitonin (PCT) levels of peritoneal dialysis (PD) patients. METHODS: We analyzed the relationship between the PCT Level and dialysis adequacy. We studied 120 peritoneal dialysis patients without signs of infection in Affiliated Hangzhou First People’s Hospital an...

Descripción completa

Detalles Bibliográficos
Autores principales: WANG, Benyong, GAO, Chan, CHEN, Qi, WANG, Ming, FEI, Xiao, ZHAO, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214616/
https://www.ncbi.nlm.nih.gov/pubmed/34178797
http://dx.doi.org/10.18502/ijph.v50i3.5591
_version_ 1783710102638821376
author WANG, Benyong
GAO, Chan
CHEN, Qi
WANG, Ming
FEI, Xiao
ZHAO, Ning
author_facet WANG, Benyong
GAO, Chan
CHEN, Qi
WANG, Ming
FEI, Xiao
ZHAO, Ning
author_sort WANG, Benyong
collection PubMed
description BACKGROUND: To detect the serum procalcitonin (PCT) levels of peritoneal dialysis (PD) patients. METHODS: We analyzed the relationship between the PCT Level and dialysis adequacy. We studied 120 peritoneal dialysis patients without signs of infection in Affiliated Hangzhou First People’s Hospital and 120 controls from Jan 2014 to Apr 2016. PCT and high sensitivity C-reactive protein (hs-CRP) were detected. 120 PD patients were divided into two groups according to the dialysis adequacy. A correlation analysis was processed between the PCT level and the total solute clearance (Kt/V). The value of PCT for identifying the dialysis adequacy in PD patients was assessed by ROC curve analysis. RESULTS: PCT level in serum of PD group (0.29±0.24 ng/ml) was higher than that of the control group (0.02±0.01 ng/ml) (P<0.01). Compared with the inadequate dialysis group (0.5±0.37 ng/ml), the PCT Level of the adequate dialysis group (0.23±0.15 ng/ml) was lower (P<0.01). There were negative correlations between PCT and Kt/v(r=−0.451), Prealbumin (PA) (r=−0.258), Glomerular Filtration Rate (eGFR; r=−0.280), while there was positive correlation between PCT and Hypersensitive c-reactive protein (r=0.458) (P<0.01). At a serum PCT cut-off value of 0.283 ng/ml, the sensitivity and specificity for identifying the dialysis adequacy in PD patients were 0.913 and 0.805 respectively. The serum levels of PCT in peritoneal dialysis patients were significantly higher than the levels in healthy controls. CONCLUSION: The serum level of PCT can be used as an indirect maker to evaluate the adequacy of dialysis.
format Online
Article
Text
id pubmed-8214616
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Tehran University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-82146162021-06-25 The Relationship between Serum Procalcitonin and Dialysis Adequacy in Peritoneal Dialysis Patients WANG, Benyong GAO, Chan CHEN, Qi WANG, Ming FEI, Xiao ZHAO, Ning Iran J Public Health Original Article BACKGROUND: To detect the serum procalcitonin (PCT) levels of peritoneal dialysis (PD) patients. METHODS: We analyzed the relationship between the PCT Level and dialysis adequacy. We studied 120 peritoneal dialysis patients without signs of infection in Affiliated Hangzhou First People’s Hospital and 120 controls from Jan 2014 to Apr 2016. PCT and high sensitivity C-reactive protein (hs-CRP) were detected. 120 PD patients were divided into two groups according to the dialysis adequacy. A correlation analysis was processed between the PCT level and the total solute clearance (Kt/V). The value of PCT for identifying the dialysis adequacy in PD patients was assessed by ROC curve analysis. RESULTS: PCT level in serum of PD group (0.29±0.24 ng/ml) was higher than that of the control group (0.02±0.01 ng/ml) (P<0.01). Compared with the inadequate dialysis group (0.5±0.37 ng/ml), the PCT Level of the adequate dialysis group (0.23±0.15 ng/ml) was lower (P<0.01). There were negative correlations between PCT and Kt/v(r=−0.451), Prealbumin (PA) (r=−0.258), Glomerular Filtration Rate (eGFR; r=−0.280), while there was positive correlation between PCT and Hypersensitive c-reactive protein (r=0.458) (P<0.01). At a serum PCT cut-off value of 0.283 ng/ml, the sensitivity and specificity for identifying the dialysis adequacy in PD patients were 0.913 and 0.805 respectively. The serum levels of PCT in peritoneal dialysis patients were significantly higher than the levels in healthy controls. CONCLUSION: The serum level of PCT can be used as an indirect maker to evaluate the adequacy of dialysis. Tehran University of Medical Sciences 2021-03 /pmc/articles/PMC8214616/ /pubmed/34178797 http://dx.doi.org/10.18502/ijph.v50i3.5591 Text en Copyright © 2021 Wang et al. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
WANG, Benyong
GAO, Chan
CHEN, Qi
WANG, Ming
FEI, Xiao
ZHAO, Ning
The Relationship between Serum Procalcitonin and Dialysis Adequacy in Peritoneal Dialysis Patients
title The Relationship between Serum Procalcitonin and Dialysis Adequacy in Peritoneal Dialysis Patients
title_full The Relationship between Serum Procalcitonin and Dialysis Adequacy in Peritoneal Dialysis Patients
title_fullStr The Relationship between Serum Procalcitonin and Dialysis Adequacy in Peritoneal Dialysis Patients
title_full_unstemmed The Relationship between Serum Procalcitonin and Dialysis Adequacy in Peritoneal Dialysis Patients
title_short The Relationship between Serum Procalcitonin and Dialysis Adequacy in Peritoneal Dialysis Patients
title_sort relationship between serum procalcitonin and dialysis adequacy in peritoneal dialysis patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214616/
https://www.ncbi.nlm.nih.gov/pubmed/34178797
http://dx.doi.org/10.18502/ijph.v50i3.5591
work_keys_str_mv AT wangbenyong therelationshipbetweenserumprocalcitoninanddialysisadequacyinperitonealdialysispatients
AT gaochan therelationshipbetweenserumprocalcitoninanddialysisadequacyinperitonealdialysispatients
AT chenqi therelationshipbetweenserumprocalcitoninanddialysisadequacyinperitonealdialysispatients
AT wangming therelationshipbetweenserumprocalcitoninanddialysisadequacyinperitonealdialysispatients
AT feixiao therelationshipbetweenserumprocalcitoninanddialysisadequacyinperitonealdialysispatients
AT zhaoning therelationshipbetweenserumprocalcitoninanddialysisadequacyinperitonealdialysispatients
AT wangbenyong relationshipbetweenserumprocalcitoninanddialysisadequacyinperitonealdialysispatients
AT gaochan relationshipbetweenserumprocalcitoninanddialysisadequacyinperitonealdialysispatients
AT chenqi relationshipbetweenserumprocalcitoninanddialysisadequacyinperitonealdialysispatients
AT wangming relationshipbetweenserumprocalcitoninanddialysisadequacyinperitonealdialysispatients
AT feixiao relationshipbetweenserumprocalcitoninanddialysisadequacyinperitonealdialysispatients
AT zhaoning relationshipbetweenserumprocalcitoninanddialysisadequacyinperitonealdialysispatients