Cargando…

Mitochondrial STAT5A promotes metabolic remodeling and the Warburg effect by inactivating the pyruvate dehydrogenase complex

Signal transducer and activator 5a (STAT5A) is a classical transcription factor that plays pivotal roles in various biological processes, including tumor initiation and progression. A fraction of STAT5A is localized in the mitochondria, but the biological functions of mitochondrial STAT5A remain obs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Liang, Zhang, Jianong, Liu, Yan, Zhang, Pingzhao, Nie, Ji, Zhao, Rui, Shi, Qin, Sun, Huiru, Jiao, Dongyue, Chen, Yingji, Zhao, Xiaying, Huang, Yan, Li, Yao, Zhao, Jian-Yuan, Xu, Wei, Zhao, Shi-Min, Wang, Chenji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214628/ https://www.ncbi.nlm.nih.gov/pubmed/34148062 http://dx.doi.org/10.1038/s41419-021-03908-0

Ejemplares similares

iASPP–PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation
por: Gao, Kun, et al.
Publicado: (2018)

Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation
por: Chen, Yingji, et al.
Publicado: (2023)

Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation
por: Jin, Yue, et al.
Publicado: (2016)

Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly
por: Shi, Qing, et al.
Publicado: (2019)

SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF
por: Feng, Kai, et al.
Publicado: (2022)

Hexokinase II promotes the Warburg effect by phosphorylating alpha subunit of pyruvate dehydrogenase
por: Luo, Fangxiu, et al.
Publicado: (2019)

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
por: Saunier, Elise, et al.
Publicado: (2017)

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
por: Park, Sungmi, et al.
Publicado: (2018)

Role of pyruvate dehydrogenase complex in traumatic brain injury and Measurement of pyruvate dehydrogenase enzyme by dipstick test
por: Sharma, Pushpa, et al.
Publicado: (2009)

Overexpression of Pyruvate Dehydrogenase E1α Subunit Inhibits Warburg Effect and Induces Cell Apoptosis Through Mitochondria-Mediated Pathway in Hepatocellular Carcinoma
por: Sun, Jihong, et al.
Publicado: (2019)

Genetic Inactivation of Pyruvate Dehydrogenase Kinases Improves Hepatic Insulin Resistance Induced Diabetes
por: Tao, Rongya, et al.
Publicado: (2013)

Pyruvate dehydrogenase deficiency disease detected by the enzyme activity of peripheral leukocytes
por: Ma, YanYan, et al.
Publicado: (2021)

Suppressed “Warburg Effect” in Nasopharyngeal Carcinoma Via the Inhibition of Pyruvate Kinase Type M2-Mediated Energy Generation Pathway
por: Zhao, Penglong, et al.
Publicado: (2020)

Reversal of the Warburg effect with DCA in PDGF-treated human PASMC is potentiated by pyruvate dehydrogenase kinase-1 inhibition mediated through blocking Akt/GSK-3β signalling
por: Li, Bingbing, et al.
Publicado: (2018)

The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina
por: Rajala, Raju V. S., et al.
Publicado: (2016)

Enzymatic Activation of Pyruvate Kinase Increases Cytosolic Oxaloacetate to Inhibit the Warburg Effect
por: Wiese, Elizabeth K., et al.
Publicado: (2021)

STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism
por: Xu, Yan S., et al.
Publicado: (2016)

Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol
por: Zhou, Ming, et al.
Publicado: (2010)

Effects of arsenic on pyruvate dehydrogenase activation.
por: Schiller, C M, et al.
Publicado: (1977)

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
por: Jeong, Ji Yun, et al.
Publicado: (2012)

Pyruvate dehydrogenase levels are low in sepsis
por: Nuzzo, E, et al.
Publicado: (2015)

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
por: Zhang, Shuai, et al.
Publicado: (2014)

Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
por: Wang, Xiuxiu, et al.
Publicado: (2021)

Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes
por: Yao, Yuan, et al.
Publicado: (2023)

A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency
por: Bedoyan, Jirair K., et al.
Publicado: (2019)

Engineering of Serine-Deamination pathway, Entner-Doudoroff pathway and pyruvate dehydrogenase complex to improve poly(3-hydroxybutyrate) production in Escherichia coli
por: Zhang, Yan, et al.
Publicado: (2014)

SPOP mutation induces DNA methylation via stabilizing GLP/G9a
por: Zhang, Jianong, et al.
Publicado: (2021)

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells
por: Moore, Jonathan D., et al.
Publicado: (2014)

Phosphorylated form of pyruvate dehydrogenase α1 mediates tumor necrosis factor α-induced glioma cell migration
por: Yang, Zijun, et al.
Publicado: (2021)

KCTD7 mutations impair the trafficking of lysosomal enzymes through CLN5 accumulation to cause neuronal ceroid lipofuscinoses
por: Wang, Yalan, et al.
Publicado: (2022)

PTEN loss promotes Warburg effect and prostate cancer cell growth by inducing FBP1 degradation
por: Song, Changze, et al.
Publicado: (2022)

β-hydroxybutyrate impairs bovine oocyte maturation via pyruvate dehydrogenase (PDH) associated energy metabolism abnormality
por: Zhang, Kai-Yan, et al.
Publicado: (2023)

The mitochondrial pyruvate carrier as a mediator of the Warburg Effect and its impact on cancer growth and metabolism
por: Schell, John, et al.
Publicado: (2014)

The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy
por: Zeng, Zhenhua, et al.
Publicado: (2021)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
por: Lee, In-Kyu
Publicado: (2014)

Phenylbutyrate increases activity of pyruvate dehydrogenase complex
por: Ferriero, Rosa, et al.
Publicado: (2013)

Astragaloside IV Alleviates the Experimental DSS-Induced Colitis by Remodeling Macrophage Polarization Through STAT Signaling
por: Tian, Lianlian, et al.
Publicado: (2021)

Asp295 Stabilizes the Active-Site Loop Structure of Pyruvate Dehydrogenase, Facilitating Phosphorylation of Ser292 by Pyruvate Dehydrogenase-Kinase
por: Hirani, Tripty A., et al.
Publicado: (2011)

Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via regulation of pyruvate dehydrogenase phosphorylation
por: Ikizawa, Takeshi, et al.
Publicado: (2022)

STAT3, HIF-1, glucose addiction and Warburg effect
por: Darnell, James E.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_0ipu9m5d9nka5strtjd5c1ij2p