Accurate genomic variant detection in single cells with primary template-directed amplification

Improvements in whole genome amplification (WGA) would enable new types of basic and applied biomedical research, including studies of intratissue genetic diversity that require more accurate single-cell genotyping. Here, we present primary template-directed amplification (PTA), an isothermal WGA me...

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Detalles Bibliográficos
Autores principales: Gonzalez-Pena, Veronica, Natarajan, Sivaraman, Xia, Yuntao, Klein, David, Carter, Robert, Pang, Yakun, Shaner, Bridget, Annu, Kavya, Putnam, Daniel, Chen, Wenan, Connelly, Jon, Pruett-Miller, Shondra, Chen, Xiang, Easton, John, Gawad, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214697/
https://www.ncbi.nlm.nih.gov/pubmed/34099548
http://dx.doi.org/10.1073/pnas.2024176118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214697/
https://www.ncbi.nlm.nih.gov/pubmed/34099548
http://dx.doi.org/10.1073/pnas.2024176118

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