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Accurate genomic variant detection in single cells with primary template-directed amplification

Improvements in whole genome amplification (WGA) would enable new types of basic and applied biomedical research, including studies of intratissue genetic diversity that require more accurate single-cell genotyping. Here, we present primary template-directed amplification (PTA), an isothermal WGA me...

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Detalles Bibliográficos
Autores principales:	Gonzalez-Pena, Veronica, Natarajan, Sivaraman, Xia, Yuntao, Klein, David, Carter, Robert, Pang, Yakun, Shaner, Bridget, Annu, Kavya, Putnam, Daniel, Chen, Wenan, Connelly, Jon, Pruett-Miller, Shondra, Chen, Xiang, Easton, John, Gawad, Charles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214697/ https://www.ncbi.nlm.nih.gov/pubmed/34099548 http://dx.doi.org/10.1073/pnas.2024176118

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