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Western lifestyle as a driver of dysbiosis in colorectal cancer
Landmark discoveries in the gut microbiome field have paved the way for new research aimed at illuminating the influence of microbiota in colorectal cancer. A major challenge is to account for the effect of inherently variable environmental factors on the host and the gut microbiome, while concurren...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214737/ https://www.ncbi.nlm.nih.gov/pubmed/34060626 http://dx.doi.org/10.1242/dmm.049051 |
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author | Foegeding, Nora J. Jones, Zachary S. Byndloss, Mariana X. |
author_facet | Foegeding, Nora J. Jones, Zachary S. Byndloss, Mariana X. |
author_sort | Foegeding, Nora J. |
collection | PubMed |
description | Landmark discoveries in the gut microbiome field have paved the way for new research aimed at illuminating the influence of microbiota in colorectal cancer. A major challenge is to account for the effect of inherently variable environmental factors on the host and the gut microbiome, while concurrently determining their contribution to carcinogenesis. Here, we briefly discuss the role of the gut microbial community in colorectal cancer and elaborate on the recent insight that environmental factors related to a Western diet and lifestyle may drive the bloom of tumorigenic members of the gut microbiota. We also discuss how future research focused on untangling host-microbe interactions in the colon may influence medical insights that relate to the prevention and treatment of colorectal cancer. |
format | Online Article Text |
id | pubmed-8214737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Company of Biologists Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-82147372021-06-21 Western lifestyle as a driver of dysbiosis in colorectal cancer Foegeding, Nora J. Jones, Zachary S. Byndloss, Mariana X. Dis Model Mech Perspective Landmark discoveries in the gut microbiome field have paved the way for new research aimed at illuminating the influence of microbiota in colorectal cancer. A major challenge is to account for the effect of inherently variable environmental factors on the host and the gut microbiome, while concurrently determining their contribution to carcinogenesis. Here, we briefly discuss the role of the gut microbial community in colorectal cancer and elaborate on the recent insight that environmental factors related to a Western diet and lifestyle may drive the bloom of tumorigenic members of the gut microbiota. We also discuss how future research focused on untangling host-microbe interactions in the colon may influence medical insights that relate to the prevention and treatment of colorectal cancer. The Company of Biologists Ltd 2021-06-01 /pmc/articles/PMC8214737/ /pubmed/34060626 http://dx.doi.org/10.1242/dmm.049051 Text en © 2021. Published by The Company of Biologists Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Perspective Foegeding, Nora J. Jones, Zachary S. Byndloss, Mariana X. Western lifestyle as a driver of dysbiosis in colorectal cancer |
title | Western lifestyle as a driver of dysbiosis in colorectal cancer |
title_full | Western lifestyle as a driver of dysbiosis in colorectal cancer |
title_fullStr | Western lifestyle as a driver of dysbiosis in colorectal cancer |
title_full_unstemmed | Western lifestyle as a driver of dysbiosis in colorectal cancer |
title_short | Western lifestyle as a driver of dysbiosis in colorectal cancer |
title_sort | western lifestyle as a driver of dysbiosis in colorectal cancer |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214737/ https://www.ncbi.nlm.nih.gov/pubmed/34060626 http://dx.doi.org/10.1242/dmm.049051 |
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