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Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia
The global COVID-19 pandemic caused by SARS-CoV-2 predominantly affects the elderly. Differential expression of SARS-CoV-2 entry genes may underlie the variable susceptibility in different patient groups. Here, we examined the gene expression of key SARS-CoV-2 entry factors in mucosal biopsies to de...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214754/ https://www.ncbi.nlm.nih.gov/pubmed/34157565 http://dx.doi.org/10.1016/j.virol.2021.05.012 |
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author | Plaas, Mihkel Seppa, Kadri Gaur, Nayana Kasenõmm, Priit Plaas, Mario |
author_facet | Plaas, Mihkel Seppa, Kadri Gaur, Nayana Kasenõmm, Priit Plaas, Mario |
author_sort | Plaas, Mihkel |
collection | PubMed |
description | The global COVID-19 pandemic caused by SARS-CoV-2 predominantly affects the elderly. Differential expression of SARS-CoV-2 entry genes may underlie the variable susceptibility in different patient groups. Here, we examined the gene expression of key SARS-CoV-2 entry factors in mucosal biopsies to delineate the roles of age and existing chronic airway disease. A significant inverse correlation between ACE2 and age and a downregulation of NRP1 in patients with airway disease were noted. These results indicate that the interplay between various factors may influence susceptibility and the disease course. |
format | Online Article Text |
id | pubmed-8214754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82147542021-06-21 Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia Plaas, Mihkel Seppa, Kadri Gaur, Nayana Kasenõmm, Priit Plaas, Mario Virology Article The global COVID-19 pandemic caused by SARS-CoV-2 predominantly affects the elderly. Differential expression of SARS-CoV-2 entry genes may underlie the variable susceptibility in different patient groups. Here, we examined the gene expression of key SARS-CoV-2 entry factors in mucosal biopsies to delineate the roles of age and existing chronic airway disease. A significant inverse correlation between ACE2 and age and a downregulation of NRP1 in patients with airway disease were noted. These results indicate that the interplay between various factors may influence susceptibility and the disease course. Elsevier Inc. 2021-09 2021-06-18 /pmc/articles/PMC8214754/ /pubmed/34157565 http://dx.doi.org/10.1016/j.virol.2021.05.012 Text en © 2021 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Plaas, Mihkel Seppa, Kadri Gaur, Nayana Kasenõmm, Priit Plaas, Mario Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia |
title | Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia |
title_full | Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia |
title_fullStr | Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia |
title_full_unstemmed | Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia |
title_short | Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia |
title_sort | age- and airway disease related gene expression patterns of key sars-cov-2 entry factors in human nasal epithelia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214754/ https://www.ncbi.nlm.nih.gov/pubmed/34157565 http://dx.doi.org/10.1016/j.virol.2021.05.012 |
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