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Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia

The global COVID-19 pandemic caused by SARS-CoV-2 predominantly affects the elderly. Differential expression of SARS-CoV-2 entry genes may underlie the variable susceptibility in different patient groups. Here, we examined the gene expression of key SARS-CoV-2 entry factors in mucosal biopsies to de...

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Detalles Bibliográficos
Autores principales: Plaas, Mihkel, Seppa, Kadri, Gaur, Nayana, Kasenõmm, Priit, Plaas, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214754/
https://www.ncbi.nlm.nih.gov/pubmed/34157565
http://dx.doi.org/10.1016/j.virol.2021.05.012
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author Plaas, Mihkel
Seppa, Kadri
Gaur, Nayana
Kasenõmm, Priit
Plaas, Mario
author_facet Plaas, Mihkel
Seppa, Kadri
Gaur, Nayana
Kasenõmm, Priit
Plaas, Mario
author_sort Plaas, Mihkel
collection PubMed
description The global COVID-19 pandemic caused by SARS-CoV-2 predominantly affects the elderly. Differential expression of SARS-CoV-2 entry genes may underlie the variable susceptibility in different patient groups. Here, we examined the gene expression of key SARS-CoV-2 entry factors in mucosal biopsies to delineate the roles of age and existing chronic airway disease. A significant inverse correlation between ACE2 and age and a downregulation of NRP1 in patients with airway disease were noted. These results indicate that the interplay between various factors may influence susceptibility and the disease course.
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spelling pubmed-82147542021-06-21 Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia Plaas, Mihkel Seppa, Kadri Gaur, Nayana Kasenõmm, Priit Plaas, Mario Virology Article The global COVID-19 pandemic caused by SARS-CoV-2 predominantly affects the elderly. Differential expression of SARS-CoV-2 entry genes may underlie the variable susceptibility in different patient groups. Here, we examined the gene expression of key SARS-CoV-2 entry factors in mucosal biopsies to delineate the roles of age and existing chronic airway disease. A significant inverse correlation between ACE2 and age and a downregulation of NRP1 in patients with airway disease were noted. These results indicate that the interplay between various factors may influence susceptibility and the disease course. Elsevier Inc. 2021-09 2021-06-18 /pmc/articles/PMC8214754/ /pubmed/34157565 http://dx.doi.org/10.1016/j.virol.2021.05.012 Text en © 2021 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Plaas, Mihkel
Seppa, Kadri
Gaur, Nayana
Kasenõmm, Priit
Plaas, Mario
Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia
title Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia
title_full Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia
title_fullStr Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia
title_full_unstemmed Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia
title_short Age- and airway disease related gene expression patterns of key SARS-CoV-2 entry factors in human nasal epithelia
title_sort age- and airway disease related gene expression patterns of key sars-cov-2 entry factors in human nasal epithelia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214754/
https://www.ncbi.nlm.nih.gov/pubmed/34157565
http://dx.doi.org/10.1016/j.virol.2021.05.012
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