Effect of clinical isolate or cleavage site mutations in the SARS-CoV-2 spike protein on protein stability, cleavage, and cell–cell fusion

The trimeric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) is the sole viral protein responsible for both viral binding to a host cell and the membrane fusion event needed for cell entry. In addition to facilitating fusion needed for viral entry, S can also drive cel...

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Detalles Bibliográficos
Autores principales: Barrett, Chelsea T., Neal, Hadley E., Edmonds, Kearstin, Moncman, Carole L., Thompson, Rachel, Branttie, Jean M., Boggs, Kerri Beth, Wu, Cheng-Yu, Leung, Daisy W., Dutch, Rebecca E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214756/
https://www.ncbi.nlm.nih.gov/pubmed/34157282
http://dx.doi.org/10.1016/j.jbc.2021.100902

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