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Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrP(C)

Expression of the cellular prion protein (PrP(C)) is crucial for the development of prion diseases. Amino acid changes in PrP(C) or a reduced amount of PrP(C) may modulate disease resistance. The relative abundance of C1, a natural α-cleavage fragment of PrP(C), was previously found to be associated...

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Detalles Bibliográficos
Autores principales:	Madsen-Bouterse, Sally A., Stewart, Paula, Williamson, Helen, Schneider, David A., Goldmann, Wilfred
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214774/ https://www.ncbi.nlm.nih.gov/pubmed/34147084 http://dx.doi.org/10.1186/s12711-021-00646-x

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