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Shifts in gut and vaginal microbiomes are associated with cancer recurrence time in women with ovarian cancer

Many studies investigating the human microbiome-cancer interface have focused on the gut microbiome and gastrointestinal cancers. Outside of human papillomavirus driving cervical cancer, little is known about the relationship between the vaginal microbiome and other gynecological cancers, such as ov...

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Autores principales: Jacobson, David, Moore, Kathleen, Gunderson, Camille, Rowland, Michelle, Austin, Rita, Honap, Tanvi Prasad, Xu, Jiawu, Warinner, Christina, Sankaranarayanan, Krithivasan, Lewis Jr, Cecil M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214851/
https://www.ncbi.nlm.nih.gov/pubmed/34178459
http://dx.doi.org/10.7717/peerj.11574
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author Jacobson, David
Moore, Kathleen
Gunderson, Camille
Rowland, Michelle
Austin, Rita
Honap, Tanvi Prasad
Xu, Jiawu
Warinner, Christina
Sankaranarayanan, Krithivasan
Lewis Jr, Cecil M.
author_facet Jacobson, David
Moore, Kathleen
Gunderson, Camille
Rowland, Michelle
Austin, Rita
Honap, Tanvi Prasad
Xu, Jiawu
Warinner, Christina
Sankaranarayanan, Krithivasan
Lewis Jr, Cecil M.
author_sort Jacobson, David
collection PubMed
description Many studies investigating the human microbiome-cancer interface have focused on the gut microbiome and gastrointestinal cancers. Outside of human papillomavirus driving cervical cancer, little is known about the relationship between the vaginal microbiome and other gynecological cancers, such as ovarian cancer. In this retrospective study, we investigated the relationship between ovarian cancer, platinum-free interval (PFI) length, and vaginal and gut microbiomes. We observed that Lactobacillus-dominated vaginal communities were less common in women with ovarian cancer, as compared to existing datasets of similarly aged women without cancer. Primary platinum-resistance (PPR) disease is strongly associated with survivability under one year, and we found over one-third of patients with PPR (PFI < 6 months, n = 17) to have a vaginal microbiome dominated by Escherichia (>20% relative abundance), while only one platinum super-sensitive (PFI > 24 months, n = 23) patient had an Escherichia-dominated microbiome. Additionally, L. iners was associated with little, or no, gross residual disease, while other Lactobacillus species were dominant in women with >1 cm gross residual disease. In the gut microbiome, we found patients with PPR disease to have lower phylogenetic diversity than platinum-sensitive patients. The trends we observe in women with ovarian cancer and PPR disease, such as the absence of Lactobacillus and presence of Escherichia in the vaginal microbiome as well as low gut microbiome phylogenetic diversity have all been linked to other diseases and/or pro-inflammatory states, including bacterial vaginosis and autoimmune disorders. Future prospective studies are necessary to explore the translational potential and underlying mechanisms driving these associations.
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spelling pubmed-82148512021-06-25 Shifts in gut and vaginal microbiomes are associated with cancer recurrence time in women with ovarian cancer Jacobson, David Moore, Kathleen Gunderson, Camille Rowland, Michelle Austin, Rita Honap, Tanvi Prasad Xu, Jiawu Warinner, Christina Sankaranarayanan, Krithivasan Lewis Jr, Cecil M. PeerJ Genetics Many studies investigating the human microbiome-cancer interface have focused on the gut microbiome and gastrointestinal cancers. Outside of human papillomavirus driving cervical cancer, little is known about the relationship between the vaginal microbiome and other gynecological cancers, such as ovarian cancer. In this retrospective study, we investigated the relationship between ovarian cancer, platinum-free interval (PFI) length, and vaginal and gut microbiomes. We observed that Lactobacillus-dominated vaginal communities were less common in women with ovarian cancer, as compared to existing datasets of similarly aged women without cancer. Primary platinum-resistance (PPR) disease is strongly associated with survivability under one year, and we found over one-third of patients with PPR (PFI < 6 months, n = 17) to have a vaginal microbiome dominated by Escherichia (>20% relative abundance), while only one platinum super-sensitive (PFI > 24 months, n = 23) patient had an Escherichia-dominated microbiome. Additionally, L. iners was associated with little, or no, gross residual disease, while other Lactobacillus species were dominant in women with >1 cm gross residual disease. In the gut microbiome, we found patients with PPR disease to have lower phylogenetic diversity than platinum-sensitive patients. The trends we observe in women with ovarian cancer and PPR disease, such as the absence of Lactobacillus and presence of Escherichia in the vaginal microbiome as well as low gut microbiome phylogenetic diversity have all been linked to other diseases and/or pro-inflammatory states, including bacterial vaginosis and autoimmune disorders. Future prospective studies are necessary to explore the translational potential and underlying mechanisms driving these associations. PeerJ Inc. 2021-06-17 /pmc/articles/PMC8214851/ /pubmed/34178459 http://dx.doi.org/10.7717/peerj.11574 Text en © 2021 Jacobson et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Genetics
Jacobson, David
Moore, Kathleen
Gunderson, Camille
Rowland, Michelle
Austin, Rita
Honap, Tanvi Prasad
Xu, Jiawu
Warinner, Christina
Sankaranarayanan, Krithivasan
Lewis Jr, Cecil M.
Shifts in gut and vaginal microbiomes are associated with cancer recurrence time in women with ovarian cancer
title Shifts in gut and vaginal microbiomes are associated with cancer recurrence time in women with ovarian cancer
title_full Shifts in gut and vaginal microbiomes are associated with cancer recurrence time in women with ovarian cancer
title_fullStr Shifts in gut and vaginal microbiomes are associated with cancer recurrence time in women with ovarian cancer
title_full_unstemmed Shifts in gut and vaginal microbiomes are associated with cancer recurrence time in women with ovarian cancer
title_short Shifts in gut and vaginal microbiomes are associated with cancer recurrence time in women with ovarian cancer
title_sort shifts in gut and vaginal microbiomes are associated with cancer recurrence time in women with ovarian cancer
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214851/
https://www.ncbi.nlm.nih.gov/pubmed/34178459
http://dx.doi.org/10.7717/peerj.11574
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